Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xrcc3provided by MGI
Official Full Name: X-ray repair complementing defective repair in Chinese hamster cells 3provided by MGI
Primary source: MGI:MGI:1921585
See related: Ensembl:ENSMUSG00000021287 AllianceGenome:MGI:1921585
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. Allelic variants in the human gene are associated with susceptibility to breast cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in ovary adult (RPKM 17.4), colon adult (RPKM 14.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.14 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111769626..111780326, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111803192..111813893, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XRCC3 loss leads to midgestational embryonic lethality in mice.
Title: XRCC3 loss leads to midgestational embryonic lethality in mice.
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
Title: Role of RAD51C and XRCC3 in genetic recombination and DNA repair.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI182522 (e-PCR)
- UniSTS:160263

AI874768 (e-PCR)
- UniSTS:165849

RH129416 (e-PCR)
- UniSTS:212723

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables crossover junction DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via synthesis-dependent strand annealing	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in resolution of mitotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
involved_in resolution of mitotic recombination intermediates	ISO Inferred from Sequence Orthology more info
involved_in resolution of mitotic recombination intermediates	ISS Inferred from Sequence or Structural Similarity more info
involved_in t-circle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in t-circle formation	IEA Inferred from Electronic Annotation more info
involved_in t-circle formation	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via recombination	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomere trimming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	ISO Inferred from Sequence Orthology more info
part_of Rad51C-XRCC3 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA repair protein XRCC3

Names: X-ray repair cross-complementing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028875.4 → NP_083151.1 DNA repair protein XRCC3

See identical proteins and their annotated locations for NP_083151.1

Status: REVIEWED

Source sequence(s)

AC152065

Consensus CDS

CCDS26187.1

UniProtKB/Swiss-Prot

Q9CXE6

Related

ENSMUSP00000021715.6, ENSMUST00000021715.6

Conserved Domains (1) summary

cd01123
Location:82 → 341

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

111769626..111780326 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246959.2 → XP_030102819.1 DNA repair protein XRCC3 isoform X1

UniProtKB/Swiss-Prot

Q9CXE6

Conserved Domains (1) summary

cd01123
Location:82 → 341

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_006516300.1 → XP_006516363.1 DNA repair protein XRCC3 isoform X2

Conserved Domains (1) summary

cl38936
Location:64 → 270

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases