Sox15 SRY (sex determining region Y)-box 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox15provided by MGI
Official Full Name: SRY (sex determining region Y)-box 15provided by MGI
Primary source: MGI:MGI:98363
See related: Ensembl:ENSMUSG00000041287 AllianceGenome:MGI:98363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sox16
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of satellite cell activation involved in skeletal muscle regeneration; and trophoblast giant cell differentiation. Acts upstream of or within several processes, including myoblast development; negative regulation of striated muscle tissue development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; incisor; and integumental system. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 12.9), placenta adult (RPKM 3.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69545863..69547553)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69655037..69656727)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both Sox7 and Sox15 are able to induce the early stages of myogenesis, but only Sox7 is sufficient to initiate the formation of fully differentiated skeletal myocytes.
Title: SOX15 and SOX7 differentially regulate the myogenic program in P19 cells.
These results suggest that the region from -297 to -8 of the Sox15 gene contains three distinct cis-elements, and that these sequences were conserved among eutherian mammals during vertebrate evolution.
Title: Mammalian Sox15 gene: promoter analysis and implications for placental evolution.
Sox15 and Sox2 have distinct roles in transcriptional control in mouse ES cells
Title: Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
Title: Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.
role in increasing Hand1 transcriptional activity might promote the transcription of the target gene resulting in the trophoblast giant cell differentiation in the mouse placenta
Title: Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491279

Sox15 (e-PCR), detects polymorphism
- UniSTS:471101

Sox15 (e-PCR), detects polymorphism
- UniSTS:265812

Sox15 (e-PCR), detects polymorphism
- UniSTS:144486

Sox15 (e-PCR), detects polymorphism
- UniSTS:516533

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of striated muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G0 to G1 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of satellite cell activation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-15

Names: SRY (sex determining region Y)-box 16; SRY-box containing gene 15; SRY-box containing gene 16; SRY-box transcription factor 15; protein SOX-15; protein SOX-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009235.2 → NP_033261.1 transcription factor SOX-15

See identical proteins and their annotated locations for NP_033261.1

Status: VALIDATED

Source sequence(s)

AK131957, BU758023

Consensus CDS

CCDS24902.1

UniProtKB/Swiss-Prot

O70204, P43267, P70418, Q62246, Q62247, Q91V00, Q91V43, Q920T1, Q9JLG2

UniProtKB/TrEMBL

Q5F2B2

Related

ENSMUSP00000048524.6, ENSMUST00000047373.6

Conserved Domains (1) summary

cd01388
Location:46 → 117

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...