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    Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13685, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eif4ebp1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 1provided by MGI
    Primary source
    MGI:MGI:103267
    See related
    Ensembl:ENSMUSG00000031490 AllianceGenome:MGI:103267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4e-bp1; PHAS-I
    Summary
    Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; insulin receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; skeletal musculature; and thymus. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 161.1), mammary gland adult (RPKM 135.9) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif4ebp1 in Genome Data Viewer
    Location:
    8 A2; 8 15.95 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27750355..27765684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27260327..27275656)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adrenergic receptor, beta 3 Neighboring gene STARR-seq mESC enhancer starr_21024 Neighboring gene predicted gene 45470 Neighboring gene STARR-seq mESC enhancer starr_21025 Neighboring gene testis expressed gene 24 pseudogene Neighboring gene cyclin Q, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic initiation factor 4E binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation repressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IRES-dependent translational initiation of linear mRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 1
    Names
    eIF4E-binding protein 1
    phosphorylated heat- and acid-stable protein regulated by insulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007918.3NP_031944.3  eukaryotic translation initiation factor 4E-binding protein 1

      See identical proteins and their annotated locations for NP_031944.3

      Status: VALIDATED

      Source sequence(s)
      AK013033, BE651550, BY318447
      Consensus CDS
      CCDS22214.1
      UniProtKB/Swiss-Prot
      Q3TDS8, Q60876, Q9CZ40
      UniProtKB/TrEMBL
      Q3TII9
      Related
      ENSMUSP00000033880.6, ENSMUST00000033880.7
      Conserved Domains (1) summary
      pfam05456
      Location:11117
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27750355..27765684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)