Magt1 magnesium transporter 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magt1provided by MGI
Official Full Name: magnesium transporter 1provided by MGI
Primary source: MGI:MGI:1914325
See related: Ensembl:ENSMUSG00000031232 AllianceGenome:MGI:1914325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAP; IAG2; 2410001C15Rik; 2610529C04Rik; 2810482I07Rik
Summary: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Used to study primary immunodeficiency disease. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 16.4), limb E14.5 (RPKM 8.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 47.36 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (105011690..105055408, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (105968084..106011802, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
Title: MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
identifed a novel gene that encodes a protein involved with Mg2+-evoked transport, MagT1; results suggest that MagT1 may provide a selective and regulated pathway for Mg2+ transport in epithelial cells[MagT1]
Title: Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (2) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	NAS Non-traceable Author Statement more info	PubMed
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
part_of oligosaccharyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of oligosaccharyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of oligosaccharyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of oligosaccharyltransferase complex	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: magnesium transporter protein 1

Names: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; implantation-associated protein; oligosaccharyl transferase subunit MAGT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190409.2 → NP_001177338.2 magnesium transporter protein 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670660, AL672288

Consensus CDS

CCDS53168.2

UniProtKB/Swiss-Prot

Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3

UniProtKB/TrEMBL

A2ADH1

Related

ENSMUSP00000120994.3, ENSMUST00000151689.9

Conserved Domains (1) summary

pfam04756
Location:42 → 330

OST3_OST6; OST3 / OST6 family, transporter family
NM_001377002.1 → NP_001363931.1 magnesium transporter protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL670660, AL672288

UniProtKB/TrEMBL

A2ADH1

Conserved Domains (1) summary

pfam04756
Location:42 → 338

OST3_OST6; OST3 / OST6 family, transporter family
NM_001377003.1 → NP_001363932.1 magnesium transporter protein 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL670660, AL672288

UniProtKB/TrEMBL

A2ADH1

Conserved Domains (1) summary

pfam04756
Location:42 → 329

OST3_OST6; OST3 / OST6 family, transporter family
NM_025952.5 → NP_080228.5 magnesium transporter protein 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL670660, AL672288

Consensus CDS

CCDS53168.2

UniProtKB/Swiss-Prot

Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3

UniProtKB/TrEMBL

A2ADH1

Related

ENSMUSP00000033583.8, ENSMUST00000033583.14

Conserved Domains (1) summary

pfam04756
Location:42 → 330

OST3_OST6; OST3 / OST6 family, transporter family