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    Il15ra interleukin 15 receptor, alpha chain [ Mus musculus (house mouse) ]

    Gene ID: 16169, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Il15raprovided by MGI
    Official Full Name
    interleukin 15 receptor, alpha chainprovided by MGI
    Primary source
    MGI:MGI:104644
    See related
    Ensembl:ENSMUSG00000023206 AllianceGenome:MGI:104644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-15RA
    Summary
    Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell differentiation. Located in cytoplasmic vesicle. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 8.1), liver E18 (RPKM 7.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il15ra in Genome Data Viewer
    Location:
    2 A1; 2 8.97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11709992..11739129)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11705172..11733985)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9504 Neighboring gene STARR-positive B cell enhancer ABC_E5884 Neighboring gene STARR-positive B cell enhancer ABC_E5885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11577075-11577258 Neighboring gene interleukin 2 receptor, alpha chain Neighboring gene STARR-seq mESC enhancer starr_03676 Neighboring gene predicted gene, 39760 Neighboring gene STARR-seq mESC enhancer starr_03677 Neighboring gene predicted gene, 39759 Neighboring gene predicted gene, 46731 Neighboring gene F-box DNA helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E804 Neighboring gene ankyrin repeat domain 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cells. Lee JM, et al. J Immunol, 2004 Sep 1. PMID 15322176
    2. Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice. Chow KP, et al. PLoS One, 2012. PMID 22448237, Free PMC Article
    3. IL-15Rα deficiency in skeletal muscle alters respiratory function and the proteome of mitochondrial subpopulations independent of changes to the mitochondrial genome. O'Connell GC, et al. Mitochondrion, 2015 Nov. PMID 26458787, Free PMC Article
    4. The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Wu Z, et al. Blood, 2008 Dec 1. PMID 18796634, Free PMC Article
    5. IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles. Pistilli EE, et al. Cytokine, 2013 Jan. PMID 23116661, Free PMC Article

    See all (161) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model.
      Title: Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model.
    2. Metabolic responses in the cortex and hippocampus induced by Il-15ralpha mutation.
      Title: Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation.
    3. IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?
      Title: IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?
    4. Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
      Title: Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
    5. IL-15/IL-15Ralpha Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models.
      Title: IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models.
    6. Our proof-of-concept preclinical studies demonstrate the safety and efficacy of the adipocyte-specific IL-15/IL-15Ralpha complex vector as a novel cancer immune gene therapy.
      Title: Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy.
    7. The higher cristae density in Il15ra (-/-) mitochondria was associated with higher OPA1 and cardiolipin levels. Overall, these data extend our understanding of the role of IL15RA signaling in muscle oxidative metabolism and adaptation to exercise.
      Title: Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.
    8. IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation.
      Title: Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα.
    9. data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion.
      Title: Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
    10. these data support that IL15RA plays a cell-autonomous role in osteoblast function and bone mineralization
      Title: IL15RA is required for osteoblast function and bone mineralization.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-15 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-15 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-15 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-15-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-15-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-15 receptor subunit alpha
    Names
    IL-15 receptor subunit alpha
    IL-15R-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271497.2 → NP_001258426.1  interleukin-15 receptor subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_001258426.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5'-most exon and uses an alternate donor splice site in another exon in the 5' UTR compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 14, and 15 all encode the same isoform (2).
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS15687.1
      UniProtKB/TrEMBL
      Q501M1
      Related
      ENSMUSP00000131473.2, ENSMUST00000138349.8

    2. NM_001271498.2 → NP_001258427.1  interleukin-15 receptor subunit alpha isoform 3

      See identical proteins and their annotated locations for NP_001258427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs and has multiple coding differences, one of which causes a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus and distinct C-terminus compared to isoform 1. Variants 4 and 17 both encode the same isoform (3).
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS70980.1
      UniProtKB/TrEMBL
      Q810T6
      Related
      ENSMUSP00000132058.2, ENSMUST00000148748.8

    3. NM_001271499.2 → NP_001258428.1  interleukin-15 receptor subunit alpha isoform 4 precursor

      See identical proteins and their annotated locations for NP_001258428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 4 (also known as isoform 1A) which is shorter than isoform 1.
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS70977.1
      UniProtKB/Swiss-Prot
      Q60819
      Related
      ENSMUSP00000110480.3, ENSMUST00000114831.9
      Conserved Domains (1) summary
      cd00033
      Location:36 → 97
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    4. NM_001271500.2 → NP_001258429.1  interleukin-15 receptor subunit alpha isoform 5 precursor

      See identical proteins and their annotated locations for NP_001258429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 5 (also known as isoform 1B) which is shorter than isoform 1.
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS70978.1
      UniProtKB/Swiss-Prot
      Q60819
      Related
      ENSMUSP00000110483.4, ENSMUST00000114834.10
      Conserved Domains (1) summary
      smart00032
      Location:36 → 96
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    5. NM_001271501.2 → NP_001258430.1  interleukin-15 receptor subunit alpha isoform 6 precursor

      See identical proteins and their annotated locations for NP_001258430.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 6 (also known as isoform 1C) which is shorter than isoform 1.
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS70979.1
      UniProtKB/Swiss-Prot
      Q60819
      Related
      ENSMUSP00000110482.4, ENSMUST00000114833.10
      Conserved Domains (1) summary
      cd00033
      Location:36 → 97
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    6. NM_001420303.1 → NP_001407232.1  interleukin-15 receptor subunit alpha isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q80SW0

    7. NM_001420304.1 → NP_001407233.1  interleukin-15 receptor subunit alpha isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q80SW0

    8. NM_001420305.1 → NP_001407234.1  interleukin-15 receptor subunit alpha isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL831794

    9. NM_001420306.1 → NP_001407235.1  interleukin-15 receptor subunit alpha isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AL831794

    10. NM_001420307.1 → NP_001407236.1  interleukin-15 receptor subunit alpha isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AL831794

    11. NM_001420308.1 → NP_001407237.1  interleukin-15 receptor subunit alpha isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL831794

    12. NM_001420310.1 → NP_001407239.1  interleukin-15 receptor subunit alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q501M1

    13. NM_001420311.1 → NP_001407240.1  interleukin-15 receptor subunit alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q501M1
      Related
      ENSMUSP00000132731.3, ENSMUST00000135341.8

    14. NM_001420315.1 → NP_001407244.1  interleukin-15 receptor subunit alpha isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL831794

    15. NM_001420317.1 → NP_001407246.1  interleukin-15 receptor subunit alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q810T6

    16. NM_001420318.1 → NP_001407247.1  interleukin-15 receptor subunit alpha isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL831794
      UniProtKB/TrEMBL
      Q80SW0

    17. NM_001420319.1 → NP_001407248.1  interleukin-15 receptor subunit alpha isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL831794

    18. NM_001420321.1 → NP_001407250.1  interleukin-15 receptor subunit alpha isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL831794

    19. NM_008358.3 → NP_032384.1  interleukin-15 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_032384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS15686.1
      UniProtKB/Swiss-Prot
      A2AP35, A2AP36, A2AP37, Q60819, Q80Z90, Q80Z91, Q80Z92, Q8R5E4
      Related
      ENSMUSP00000077878.6, ENSMUST00000078834.12
      Conserved Domains (1) summary
      cd00033
      Location:36 → 97
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    20. NM_133836.3 → NP_598597.1  interleukin-15 receptor subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_598597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon in the 5' UTR compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 14, and 15 all encode the same isoform (2).
      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS15687.1
      UniProtKB/TrEMBL
      Q501M1
      Related
      ENSMUSP00000126364.2, ENSMUST00000128156.9

    RNA

    1. NR_185161.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831794

    2. NR_185162.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL831794

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11709992..11739129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247643.2 → XP_030103503.1  interleukin-15 receptor subunit alpha isoform X6

    2. XM_030247644.2 → XP_030103504.1  interleukin-15 receptor subunit alpha isoform X7

      UniProtKB/TrEMBL
      Q501M1

    3. XM_017315695.3 → XP_017171184.1  interleukin-15 receptor subunit alpha isoform X5

      UniProtKB/Swiss-Prot
      Q60819
      Related
      ENSMUSP00000110481.3, ENSMUST00000114832.3
      Conserved Domains (1) summary
      cd00033
      Location:36 → 97
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    4. XM_006497359.4 → XP_006497422.1  interleukin-15 receptor subunit alpha isoform X2

      Conserved Domains (1) summary
      cd00033
      Location:36 → 97
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    5. XM_006497360.4 → XP_006497423.1  interleukin-15 receptor subunit alpha isoform X3

    RNA

    1. XR_003950824.2 RNA Sequence

    2. XR_865926.4 RNA Sequence

    3. XR_004938395.1 RNA Sequence

    4. XR_865924.4 RNA Sequence

    5. XR_865925.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_073191.1: Suppressed sequence

      Description
      NR_073191.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

    2. NR_073192.1: Suppressed sequence

      Description
      NR_073192.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60819.1 GenPept UniProtKB/Swiss-Prot:Q60819

    Gene LinkOut

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