Pfdn1 prefoldin subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pfdn1provided by RGD
Official Full Name: prefoldin subunit 1provided by RGD
Primary source: RGD:1305603
See related: EnsemblRapid:ENSRNOG00000018653 AllianceGenome:RGD:1305603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 586.5), Heart (RPKM 395.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (28288210..28341198, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (28014145..28067148, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (29233987..29290447, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D18Rat35 (e-PCR)
- UniSTS:119339

PMC350564P1 (e-PCR)
- UniSTS:273240

PMC18810P1 (e-PCR)
- UniSTS:271733

RH128014 (e-PCR)
- UniSTS:211323

D18Rat59 (e-PCR)
- UniSTS:118469

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prefoldin subunit 1

Names: prefoldin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108427.1 → NP_001101897.1 prefoldin subunit 1

See identical proteins and their annotated locations for NP_001101897.1

Status: PROVISIONAL

Source sequence(s)

CH473974

UniProtKB/TrEMBL

A0A8I6A4I0, A6J311, D3ZX38

Related

ENSRNOP00000025353.4, ENSRNOT00000025353.7

Conserved Domains (1) summary

pfam01920
Location:17 → 117

Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

28288210..28341198 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096961.2 → XP_038952889.1 prefoldin subunit 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A3F6

Related

ENSRNOP00000085908.1, ENSRNOT00000099632.2

Conserved Domains (1) summary

cl09111
Location:17 → 67

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...