C1qbp complement C1q binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qbpprovided by RGD
Official Full Name: complement C1q binding proteinprovided by RGD
Primary source: RGD:2230
See related: EnsemblRapid:ENSRNOG00000006949 AllianceGenome:RGD:2230
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Habp1; gC1qR
Summary: Enables adrenergic receptor binding activity; complement component C1q complex binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell migration; and regulation of intracellular signal transduction. Located in cytoplasm and extracellular space. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 241.6), Adrenal (RPKM 231.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (56198534..56203185, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55699954..55704605, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57613876..57618527, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that disrupted ovarian hyaluronan binding protein 1 (HABP1) along with concurrent altered expression and hyperactivation of related MMPs can lead to abnormal follicular maturation resulting into ovarian dysfunction in polycystic ovary (PCO).
Title: Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat.
findings indicate a possible role for HABP1 proprotein in apoptosis induction of germ cells in the cryptorchid testes
Title: Simultaneous accumulation of hyaluronan binding protein 1 (HABP1/p32/gC1qR) and apoptotic induction of germ cells in cryptorchid testis.
The present study provides evidence of the ability of soluble gC1qR to enhance S. aureus-fibrinogen interactions via simultaneously binding fibrinogen and S. aureus in a S. aureus endocarditis model. [gClqR/p33]
Title: gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis.
Rat and mouse homologs of the HABP1 pseudogene also contain multiple mutations, leading to the insertion of premature stop codons confirming the identity of a processed pseudogene.
Title: Evidence for the presence of HABP1 pseudogene in multiple locations of mammalian genome.
these findings demonstrate the appearance of HABP1 proprotein in the pachytene spermatocytes and the round spermatids during the initial stages of postnatal testis development and suggest that this expression may be crucial for spermatogenesis.
Title: Appearance of hyaluronan binding protein 1 proprotein in pachytene spermatocytes and round spermatids correlates with spermatogenesis.
These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail [gC1qR].
Title: Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.
Stage-specific expression of proprotein form of hyaluronan binding protein 1 (HABP1) during spermatogenesis in rat.
Title: Stage-specific expression of proprotein form of hyaluronan binding protein 1 (HABP1) during spermatogenesis in rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129221 (e-PCR)
- UniSTS:212529

RH129498 (e-PCR)
- UniSTS:212802

RH141362 (e-PCR)
- UniSTS:223358

RH128020 (e-PCR)
- UniSTS:211329

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C5-methylcytidine-containing RNA reader activity	IEA Inferred from Electronic Annotation more info
enables C5-methylcytidine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables adrenergic receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C1q complex binding	IDA Inferred from Direct Assay more info	PubMed
enables complement component C1q complex binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables deoxyribonuclease inhibitor activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables kininogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables kininogen binding	IEA Inferred from Electronic Annotation more info
enables kininogen binding	ISO Inferred from Sequence Orthology more info
enables kininogen binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitochondrial ribosome binding	ISO Inferred from Sequence Orthology more info
enables mitochondrial ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in cytosolic ribosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
involved_in cytosolic ribosome assembly	ISO Inferred from Sequence Orthology more info
involved_in cytosolic ribosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MDA-5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MDA-5 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RIG-I signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of trophoblast cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of trophoblast cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of complement activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of complement activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: complement component 1 Q subcomponent-binding protein, mitochondrial

Names: GC1q-R protein; complement component 1, q subcomponent binding protein; glycoprotein gC1qBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.