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    Unc79 unc-79 homolog, NALCN channel complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314401, updated on 9-Dec-2024

    Summary

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    Symbol
    Unc79provided by RGD
    Full Name
    unc-79 homolog, NALCN channel complex subunitprovided by RGD
    Primary source
    RGD:1311117
    See related
    EnsemblRapid:ENSRNOG00000008728 AllianceGenome:RGD:1311117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311117
    Summary
    Predicted to act upstream of or within behavioral response to ethanol and suckling behavior. Predicted to be located in plasma membrane. Orthologous to human UNC79 (unc-79 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 66.0), Spleen (RPKM 18.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc79 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127841671..128092380)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122082369..122327641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126818580..127069026)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene BTB domain containing 7 Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene enolase 1 like 1 Neighboring gene proline rich membrane anchor 1 Neighboring gene uncharacterized LOC120103607 Neighboring gene family with sequence similarity 181, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes. Hao L, et al. Neurosci Lett, 2019 Jun 11. PMID 30851305
    2. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. Speca DJ, et al. PLoS Genet, 2010 Aug 12. PMID 20714347, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA LOC103690121 promoted STZ-induced cognitive impairment in diabetic rats by promoting neuron apoptosis through PI3K/Akt signaling pathway
      Title: A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within suckling behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-79 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271253.2 → NP_001258182.1  protein unc-79 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZJJ4
      Conserved Domains (1) summary
      pfam14776
      Location:1 → 468
      UNC-79; Cation-channel complex subunit UNC-79

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127841671..128092380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261997.1 → XP_063118067.1  protein unc-79 homolog isoform X22

      UniProtKB/TrEMBL
      D3ZSV8

    2. XM_063261998.1 → XP_063118068.1  protein unc-79 homolog isoform X23

      UniProtKB/TrEMBL
      D3ZSV8

    3. XM_063261995.1 → XP_063118065.1  protein unc-79 homolog isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZJJ4

    4. XM_063261992.1 → XP_063118062.1  protein unc-79 homolog isoform X18

      UniProtKB/TrEMBL
      A0A8I6AJ87, D3ZSV8

    5. XM_063261990.1 → XP_063118060.1  protein unc-79 homolog isoform X16

      UniProtKB/TrEMBL
      D3ZSV8

    6. XM_063261980.1 → XP_063118050.1  protein unc-79 homolog isoform X4

      UniProtKB/TrEMBL
      D3ZSV8
      Related
      ENSRNOP00000077624.2, ENSRNOT00000107056.2

    7. XM_063261988.1 → XP_063118058.1  protein unc-79 homolog isoform X13

      UniProtKB/TrEMBL
      D3ZSV8

    8. XM_063261996.1 → XP_063118066.1  protein unc-79 homolog isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZJJ4

    9. XM_063261981.1 → XP_063118051.1  protein unc-79 homolog isoform X5

      UniProtKB/TrEMBL
      D3ZSV8

    10. XM_063261993.1 → XP_063118063.1  protein unc-79 homolog isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZJJ4

    11. XM_063261984.1 → XP_063118054.1  protein unc-79 homolog isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZJJ4

    12. XM_039112372.2 → XP_038968300.1  protein unc-79 homolog isoform X1

      UniProtKB/TrEMBL
      D3ZSV8
      Conserved Domains (1) summary
      pfam14776
      Location:141 → 672
      UNC-79; Cation-channel complex subunit UNC-79

    13. XM_063261985.1 → XP_063118055.1  protein unc-79 homolog isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLN3

    14. XM_063261994.1 → XP_063118064.1  protein unc-79 homolog isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZLN3

    15. XM_063261979.1 → XP_063118049.1  protein unc-79 homolog isoform X2

      UniProtKB/TrEMBL
      D3ZSV8

    16. XM_063261982.1 → XP_063118052.1  protein unc-79 homolog isoform X6

      UniProtKB/TrEMBL
      D3ZSV8

    17. XM_063261989.1 → XP_063118059.1  protein unc-79 homolog isoform X15

      UniProtKB/TrEMBL
      D3ZSV8

    18. XM_039112384.2 → XP_038968312.1  protein unc-79 homolog isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZLN3
      Conserved Domains (1) summary
      pfam14776
      Location:141 → 672
      UNC-79; Cation-channel complex subunit UNC-79

    19. XM_063261986.1 → XP_063118056.1  protein unc-79 homolog isoform X11

      UniProtKB/TrEMBL
      D3ZSV8

    20. XM_063261991.1 → XP_063118061.1  protein unc-79 homolog isoform X17

      UniProtKB/TrEMBL
      D3ZSV8

    21. XM_039112381.2 → XP_038968309.1  protein unc-79 homolog isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZJJ4
      Conserved Domains (1) summary
      pfam14776
      Location:88 → 619
      UNC-79; Cation-channel complex subunit UNC-79

    22. XM_063261983.1 → XP_063118053.1  protein unc-79 homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNV0, D3ZSV8

    23. XM_039112378.2 → XP_038968306.1  protein unc-79 homolog isoform X3

      UniProtKB/TrEMBL
      D3ZSV8
      Related
      ENSRNOP00000079886.2, ENSRNOT00000110508.2
      Conserved Domains (1) summary
      pfam14776
      Location:141 → 672
      UNC-79; Cation-channel complex subunit UNC-79

    24. XM_039112385.2 → XP_038968313.1  protein unc-79 homolog isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZLN3
      Conserved Domains (1) summary
      pfam14776
      Location:141 → 672
      UNC-79; Cation-channel complex subunit UNC-79

    25. XM_063261987.1 → XP_063118057.1  protein unc-79 homolog isoform X12

      UniProtKB/TrEMBL
      D3ZSV8
    Nucleotide Protein Strain
    Heading Accession and Version

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