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    Tmem170a transmembrane protein 170A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498953, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tmem170aprovided by RGD
    Official Full Name
    transmembrane protein 170Aprovided by RGD
    Primary source
    RGD:1559505
    See related
    AllianceGenome:RGD:1559505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559505
    Summary
    Predicted to be involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Orthologous to human TMEM170A (transmembrane protein 170A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 35.1), Kidney (RPKM 34.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem170a in Genome Data Viewer
    Location:
    19q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56743221..56756085, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39833947..39846807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44090418..44101365, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene BCAR1 scaffold protein, Cas family member Neighboring gene craniofacial development protein 1 Neighboring gene uncharacterized LOC134483372 Neighboring gene U6 spliceosomal RNA Neighboring gene carbohydrate sulfotransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells. Christodoulou A, et al. J Cell Sci, 2016 Apr 15. PMID 26906412, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 170A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134608.1 → NP_001128080.1  transmembrane protein 170A

      See identical proteins and their annotated locations for NP_001128080.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZB2, M0R417
      Conserved Domains (1) summary
      pfam10190
      Location:39 → 144
      Tmemb_170; Putative transmembrane protein 170

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56743221..56756085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097934.2 → XP_038953862.1  transmembrane protein 170A isoform X1

      Conserved Domains (1) summary
      pfam10190
      Location:39 → 121
      Tmemb_170; Putative transmembrane protein 170
    Nucleotide Protein Strain
    Heading Accession and Version

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