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    Kansl2 KAT8 regulatory NSL complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300206, updated on 27-Dec-2024

    Summary

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    Symbol
    Kansl2provided by RGD
    Full Name
    KAT8 regulatory NSL complex subunit 2provided by RGD
    Primary source
    RGD:1303127
    See related
    EnsemblRapid:ENSRNOG00000060185 AllianceGenome:RGD:1303127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1303127
    Summary
    Predicted to be involved in chromatin organization. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be part of NSL complex. Predicted to be active in mitochondrion. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 244.7), Thymus (RPKM 192.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kansl2 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131548062..131564876, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129669031..129685750, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140196943..140213686, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene lactalbumin, alpha Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene cyclin T1 Neighboring gene sperm microtubule inner protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94200

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KAT8 regulatory NSL complex subunit 2
    Names
    NSL complex protein NSL2
    non-specific lethal 2 homolog
    uncharacterized protein C12orf41 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004244.3 → NP_001004244.2  KAT8 regulatory NSL complex subunit 2

      See identical proteins and their annotated locations for NP_001004244.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      G3V7H0, Q6AY70
      UniProtKB/TrEMBL
      A0A0G2K3M8
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    2. NM_001421308.1 → NP_001408237.1  KAT8 regulatory NSL complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      G3V7H0, Q6AY70
      UniProtKB/TrEMBL
      A0A0G2K3M8
      Related
      ENSRNOP00000073779.2, ENSRNOT00000086886.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131548062..131564876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765693.4 → XP_008763915.1  KAT8 regulatory NSL complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_008763915.1

      UniProtKB/Swiss-Prot
      G3V7H0, Q6AY70
      UniProtKB/TrEMBL
      A0A0G2K3M8
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    2. XM_063263374.1 → XP_063119444.1  KAT8 regulatory NSL complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3Q1

    3. XM_063263375.1 → XP_063119445.1  KAT8 regulatory NSL complex subunit 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY70.2 GenPept UniProtKB/Swiss-Prot:Q6AY70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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