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    Cep128 centrosomal protein 128 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500700, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cep128provided by RGD
    Official Full Name
    centrosomal protein 128provided by RGD
    Primary source
    RGD:1595693
    See related
    EnsemblRapid:ENSRNOG00000003908 AllianceGenome:RGD:1595693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein localization. Predicted to act upstream of or within regulation of gene expression and sperm flagellum assembly. Predicted to be located in Golgi apparatus; centrosome; and nuclear membrane. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centriole and spindle pole. Orthologous to human CEP128 (centrosomal protein 128). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 156.8), Thymus (RPKM 93.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep128 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (115681753..116059758, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (109951009..110328686, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (114759474..115158004, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479242 Neighboring gene uncharacterized LOC134479243 Neighboring gene thyroid stimulating hormone receptor Neighboring gene small nucleolar RNA SNORA79 Neighboring gene general transcription factor 2A subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Sonnen KF, et al. Biol Open, 2012 Oct 15. PMID 23213374, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein 128; centrosomal protein of 128 kDa
    Names
    centrosomal protein 128kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432110.1 → NP_001419039.1  centrosomal protein 128 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A8E4

    2. NM_001432111.1 → NP_001419040.1  centrosomal protein 128 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001432112.1 → NP_001419041.1  centrosomal protein 128 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6GHX3

    4. NM_001432113.1 → NP_001419042.1  centrosomal protein 128 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      115681753..116059758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056985589.2 → XP_056841569.1  centrosomal protein of 128 kDa isoform X5

    2. XM_056985588.2 → XP_056841568.1  centrosomal protein of 128 kDa isoform X4

      Related
      ENSRNOP00000093759.2, ENSRNOT00000110851.2

    3. XM_056985587.2 → XP_056841567.1  centrosomal protein of 128 kDa isoform X3

      Related
      ENSRNOP00000089233.2, ENSRNOT00000057756.6

    4. XM_056985586.2 → XP_056841566.1  centrosomal protein of 128 kDa isoform X2

      Related
      ENSRNOP00000089524.2, ENSRNOT00000076546.3

    5. XM_056985584.2 → XP_056841564.1  centrosomal protein of 128 kDa isoform X1

    6. XM_063262692.1 → XP_063118762.1  centrosomal protein of 128 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8E4

    7. XM_056985590.2 → XP_056841570.1  centrosomal protein of 128 kDa isoform X7

    8. XM_063262693.1 → XP_063118763.1  centrosomal protein of 128 kDa isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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