Nudt6 nudix hydrolase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt6provided by RGD
Official Full Name: nudix hydrolase 6provided by RGD
Primary source: RGD:621356
See related: EnsemblRapid:ENSRNOG00000017420 AllianceGenome:RGD:621356
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gfg
Summary: Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Predicted to be involved in negative regulation of cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human NUDT6 (nudix hydrolase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 64.4), Liver (RPKM 64.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (122218031..122234488, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (120289908..120306197, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (124134301..124149824, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling.
Title: FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling.
The results suggest that the endogenous FGF antisense RNA may play a significant functional role in the regulation of FGF-2 dependent cell proliferation in FGF-2 expressing cells.
Title: The fibroblast growth factor-2 antisense gene inhibits nuclear accumulation of FGF-2 and delays cell cycle progression in C6 glioma cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130030 (e-PCR)
- UniSTS:213318

RH94418 (e-PCR)
- UniSTS:119666

RH144356 (e-PCR)
- UniSTS:233601

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADH pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH pyrophosphatase activity	IEA Inferred from Electronic Annotation more info
enables NADH pyrophosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate-linked moiety X motif 6

Names: antisense basic fibroblast growth factor; nudix (nucleoside diphosphate linked moiety X)-type motif 6; nudix motif 6

NP_852028.1

EC 3.6.1.-

XP_038957610.1

EC 3.6.1.-

XP_038957611.1

EC 3.6.1.-

XP_063137345.1

EC 3.6.1.-

XP_063137346.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181363.3 → NP_852028.1 nucleoside diphosphate-linked moiety X motif 6

See identical proteins and their annotated locations for NP_852028.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P70563, Q9QZD7

UniProtKB/TrEMBL

A6II08, A6II09

Conserved Domains (2) summary

cd04670
Location:139 → 271

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

122218031..122234488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101682.2 → XP_038957610.1 nucleoside diphosphate-linked moiety X motif 6 isoform X1

UniProtKB/TrEMBL

A6II08

Related

ENSRNOP00000104370.1, ENSRNOT00000168516.1

Conserved Domains (2) summary

cd04670
Location:139 → 271

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain
XM_063281276.1 → XP_063137346.1 nucleoside diphosphate-linked moiety X motif 6 isoform X4

UniProtKB/TrEMBL

A6II10, A6II11
XM_039101683.2 → XP_038957611.1 nucleoside diphosphate-linked moiety X motif 6 isoform X2

Conserved Domains (2) summary

cd04670
Location:66 → 198

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:4 → 53

Nudix_hydro; Nudix hydrolase domain
XM_063281275.1 → XP_063137345.1 nucleoside diphosphate-linked moiety X motif 6 isoform X3