U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cfc1 cripto, FRL-1, cryptic family 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501121, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cfc1provided by RGD
    Official Full Name
    cripto, FRL-1, cryptic family 1provided by RGD
    Primary source
    RGD:1562188
    See related
    EnsemblRapid:ENSRNOG00000042646 AllianceGenome:RGD:1562188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562188
    Summary
    Predicted to enable activin receptor binding activity and nodal binding activity. Involved in female pregnancy. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in tetralogy of Fallot and visceral heterotaxy. Orthologous to human CFC1 (cryptic, EGF-CFC family member 1) and CFC1B (cryptic, EGF-CFC family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 9.1), Lung (RPKM 5.0) and 2 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cfc1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44234997..44247846)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36742106..36751931)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41045352..41051979)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene uncharacterized LOC134480354 Neighboring gene protease, serine, 39 Neighboring gene small nucleolar RNA, H/ACA box 51 Neighboring gene protease, serine, 40 Neighboring gene RCC1 and BTB domain containing protein 1, pseudogene 1 Neighboring gene APC membrane recruitment protein 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot. Sheng W, et al. J Transl Med, 2014 Jan 31. PMID 24479926, Free PMC Article
    2. Duplication and deletion of CFC1 associated with heterotaxy syndrome. Cao R, et al. DNA Cell Biol, 2015 Feb. PMID 25423076, Free PMC Article
    3. Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo. Argañaraz ME, et al. Mol Reprod Dev, 2019 Nov. PMID 31418961
    4. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Bamford RN, et al. Nat Genet, 2000 Nov. PMID 11062482
    5. A role of the cryptic gene in the correct establishment of the left-right axis. Gaio U, et al. Curr Biol, 1999 Nov 18. PMID 10574770

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables activin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nodal binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood vessel development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in determination of left/right symmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within left lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nodal signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within respiratory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spleen development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cryptic protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109304.2 → NP_001102774.2  cryptic protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GC89, A6INA5, F1LV65
      Related
      ENSRNOP00000062738.4, ENSRNOT00000066284.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44234997..44247846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267584.1 → XP_063123654.1  cryptic protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC89, A6INA5, F1LV65
      Related
      ENSRNOP00000084880.1, ENSRNOT00000104316.2

    2. XM_039084069.2 → XP_038939997.1  cryptic protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC89, A6INA5, F1LV65
      Conserved Domains (2) summary
      cd00054
      Location:99 → 123
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam09443
      Location:131 → 165
      CFC; Cripto_Frl-1_Cryptic (CFC)

    3. XM_063267583.1 → XP_063123653.1  cryptic protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC89, A6INA5, F1LV65
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools