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    Irag2 inositol 1,4,5-triphosphate receptor associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500361, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Irag2provided by RGD
    Official Full Name
    inositol 1,4,5-triphosphate receptor associated 2provided by RGD
    Primary source
    RGD:1562062
    See related
    EnsemblRapid:ENSRNOG00000029308 AllianceGenome:RGD:1562062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrmp; RGD1562062
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in nucleus organization. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 200.0), Thymus (RPKM 161.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Irag2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179819526..179874408)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178088902..178143569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179402929..179440792)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene branched chain amino acid transaminase 1 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene uncharacterized LOC134486864 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene KRAS proto-oncogene, GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells. Shindo Y, et al. Chem Senses, 2010 Feb. PMID 20071408, Free PMC Article
    2. Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. Behrens TW, et al. J Immunol, 1994 Jul 15. PMID 8021504
    3. Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. Behrens TW, et al. J Biol Chem, 1996 Sep 20. PMID 8798562
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-triphosphate receptor associated 2
    Names
    lymphoid-restricted membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427185.2 → NP_001414114.2  inositol 1,4,5-triphosphate receptor associated 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      179819526..179874408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286587.1 → XP_063142657.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

      UniProtKB/TrEMBL
      A6IMZ5, F1LXR9

    2. XM_063286579.1 → XP_063142649.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    3. XM_063286589.1 → XP_063142659.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X5

    4. XM_063286580.1 → XP_063142650.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    5. XM_063286590.1 → XP_063142660.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X6

    6. XM_063286591.1 → XP_063142661.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X7

    7. XM_063286583.1 → XP_063142653.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X2

      Related
      ENSRNOP00000046606.7, ENSRNOT00000049474.8

    8. XM_063286586.1 → XP_063142656.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

    9. XM_063286592.1 → XP_063142662.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5Y4
      Related
      ENSRNOP00000081442.1, ENSRNOT00000093893.2

    10. XM_063286584.1 → XP_063142654.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

    11. XM_063286593.1 → XP_063142663.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5Y4

    12. XM_063286581.1 → XP_063142651.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    13. XM_063286582.1 → XP_063142652.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    14. XM_063286585.1 → XP_063142655.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

    15. XM_063286594.1 → XP_063142664.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5Y4

    16. XM_063286588.1 → XP_063142658.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

      UniProtKB/TrEMBL
      A6IMZ5, F1LXR9
      Related
      ENSRNOP00000102134.1, ENSRNOT00000150781.1
    Nucleotide Protein Strain
    Heading Accession and Version

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