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    Lman2l lectin, mannose-binding 2-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301343, updated on 9-Dec-2024

    Summary

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    Symbol
    Lman2lprovided by RGD
    Full Name
    lectin, mannose-binding 2-likeprovided by RGD
    Primary source
    RGD:1311393
    See related
    EnsemblRapid:ENSRNOG00000015699 AllianceGenome:RGD:1311393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein transport. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 25.4), Kidney (RPKM 25.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lman2l in Genome Data Viewer
    Location:
    9q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46157596..46181151, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38661709..38685244, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43020940..43023015, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene fer-1-like family member 5 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein. Nufer O, et al. J Biol Chem, 2003 May 2. PMID 12609988
    2. VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum. Neve EP, et al. Exp Cell Res, 2003 Aug 1. PMID 12878160
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VIP36-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402076.1 → NP_001389005.1  VIP36-like protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IND3, F7F3Z1
      Related
      ENSRNOP00000060837.4, ENSRNOT00000063781.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46157596..46181151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266892.1 → XP_063122962.1  VIP36-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6G604, A6IND4
      Related
      ENSRNOP00000081479.1, ENSRNOT00000117761.2

    2. XM_039084532.2 → XP_038940460.1  VIP36-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4A4
      Conserved Domains (1) summary
      cl14058
      Location:16 → 145
      lectin_L-type; legume lectins

    3. XM_039084531.2 → XP_038940459.1  VIP36-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4A4
      Related
      ENSRNOP00000086744.1, ENSRNOT00000119365.2
      Conserved Domains (1) summary
      cl14058
      Location:16 → 145
      lectin_L-type; legume lectins

    RNA

    1. XR_010054583.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106900.1: Suppressed sequence

      Description
      NM_001106900.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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