Neurl3 neuralized E3 ubiquitin protein ligase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurl3provided by RGD
Official Full Name: neuralized E3 ubiquitin protein ligase 3provided by RGD
Primary source: RGD:1359633
See related: EnsemblRapid:ENSRNOG00000015366 AllianceGenome:RGD:1359633
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lincr
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in early endosome. Orthologous to human NEURL3 (neuralized E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 77.1), Spleen (RPKM 72.6) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (45990373..45998470, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (38494486..38503352, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (42831737..42841765, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase NEURL3

Names: E3 ubiquitin-protein ligase LINCR; RING-type E3 ubiquitin transferase NEURL3; lung-inducible neuralized-related C3CH4 RING domain protein; lung-inducible neuralized-related C3HC4 RING domain protein; neuralized homolog 3; neuralized-like protein 3

NP_001014122.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014100.1 → NP_001014122.1 E3 ubiquitin-protein ligase NEURL3

See identical proteins and their annotated locations for NP_001014122.1

Status: PROVISIONAL

Source sequence(s)

BC088198

UniProtKB/Swiss-Prot

Q5M870

UniProtKB/TrEMBL

A0A8I5ZZI5

Related

ENSRNOP00000029092.3, ENSRNOT00000038610.7

Conserved Domains (2) summary

cd16552
Location:195 → 236

RING-HC_NEURL3; RING finger, HC subclass, found in neuralized-like protein 3 (NEURL3) and similar proteins

pfam07177
Location:20 → 173

Neuralized