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    Dennd2d DENN domain containing 2D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dennd2dprovided by RGD
    Official Full Name
    DENN domain containing 2Dprovided by RGD
    Primary source
    RGD:1305120
    See related
    EnsemblRapid:ENSRNOG00000017680 AllianceGenome:RGD:1305120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305120
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytosol and nucleoplasm. Orthologous to human DENND2D (DENN domain containing 2D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 102.6), Thymus (RPKM 97.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd2d in Genome Data Viewer
    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196661465..196680505)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193973231..193992275)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209097894..209116978)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene chitinase acidic-like 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 9 Neighboring gene uncharacterized LOC100912312 Neighboring gene choline/ethanolamine phosphotransferase 1 Neighboring gene DNA damage regulated autophagy modulator 2 Neighboring gene uncharacterized LOC134485947

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2D
    Names
    DENN/MADD domain containing 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107714.1 → NP_001101184.1  DENN domain-containing protein 2D

      See identical proteins and their annotated locations for NP_001101184.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I6ACY0, A6HUQ3, B0BNM5, F7FCL3
      Related
      ENSRNOP00000023807.5, ENSRNOT00000023807.7
      Conserved Domains (3) summary
      smart00801
      Location:369 → 434
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:47 → 139
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:146 → 330
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196661465..196680505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233114.5 → XP_006233176.1  DENN domain-containing protein 2D isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACY0, A0A8I6AZ21
      Related
      ENSRNOP00000094129.1, ENSRNOT00000118361.2
      Conserved Domains (3) summary
      smart00801
      Location:379 → 444
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:57 → 149
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:156 → 340
      DENN; DENN (AEX-3) domain

    2. XM_039102418.2 → XP_038958346.1  DENN domain-containing protein 2D isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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