Usp2 ubiquitin specific peptidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp2provided by RGD
Official Full Name: ubiquitin specific peptidase 2provided by RGD
Primary source: RGD:621073
See related: EnsemblRapid:ENSRNOG00000006663 AllianceGenome:RGD:621073
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UBP-t
Summary: Enables cysteine-type deubiquitinase activity. Involved in negative regulation of skeletal muscle tissue development; positive regulation of skeletal muscle tissue development; and protein deubiquitination. Located in centrosome; nucleus; and perinuclear region of cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 196.5), Muscle (RPKM 120.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53308264..53336800)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44411457..44439668)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48403985..48432525)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro.
Title: Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
results have identified USP2 as a key molecule that mediates stress-induced spatial memory retrieval impairment.
Title: Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
myogenic differentiation of embryonic muscle cells is antagonistically regulated by two deubiquitinating enzymes, UBP45 and UBP69, that are generated by alternative splicing[Usp2].
Title: Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in circadian behavior	ISO Inferred from Sequence Orthology more info
involved_in circadian behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 2

Names: 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin specific protease 2; ubiquitin thioesterase 2; ubiquitin thiolesterase 2; ubiquitin-specific-processing protease 2; ubiquitin-specific-processing protease testis

NP_446226.3

EC 3.4.19.12

XP_006242925.1

EC 3.4.19.12

XP_008764360.1

EC 3.4.19.12

XP_008764361.1

EC 3.4.19.12

XP_038936630.1

EC 3.4.19.12

XP_038936631.1

EC 3.4.19.12

XP_038936632.1

EC 3.4.19.12

XP_063120846.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053774.3 → NP_446226.3 ubiquitin carboxyl-terminal hydrolase 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084

UniProtKB/TrEMBL

A0A8L2Q4I7

Related

ENSRNOP00000078529.1, ENSRNOT00000104911.2

Conserved Domains (1) summary

pfam00443
Location:280 → 609

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

53308264..53336800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766138.4 → XP_008764360.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X3

Conserved Domains (2) summary

cd02674
Location:25 → 354

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:23 → 353

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_039080702.2 → XP_038936630.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X1

UniProtKB/Swiss-Prot

Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084

UniProtKB/TrEMBL

A0A8L2Q4I7

Conserved Domains (1) summary

pfam00443
Location:280 → 609

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_039080703.2 → XP_038936631.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X1

UniProtKB/Swiss-Prot

Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084

UniProtKB/TrEMBL

A0A8L2Q4I7

Conserved Domains (1) summary

pfam00443
Location:280 → 609

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_039080704.2 → XP_038936632.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X1

UniProtKB/Swiss-Prot

Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084

UniProtKB/TrEMBL

A0A8L2Q4I7

Conserved Domains (1) summary

pfam00443
Location:280 → 609

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_006242863.5 → XP_006242925.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X2

See identical proteins and their annotated locations for XP_006242925.1

UniProtKB/Swiss-Prot

Q5U349

Related

ENSRNOP00000030257.4, ENSRNOT00000036051.8

Conserved Domains (2) summary

cd02674
Location:59 → 388

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:57 → 387

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_008766139.3 → XP_008764361.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X4

Conserved Domains (2) summary

cd02674
Location:17 → 346

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:15 → 345

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_063264776.1 → XP_063120846.1 ubiquitin carboxyl-terminal hydrolase 2 isoform X4