Rictor RPTOR independent companion of MTOR, complex 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rictorprovided by RGD
Official Full Name: RPTOR independent companion of MTOR, complex 2provided by RGD
Primary source: RGD:1307224
See related: EnsemblRapid:ENSRNOG00000011341 AllianceGenome:RGD:1307224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including protein kinase binding activity; protein serine/threonine kinase activator activity; and ribosome binding activity. Involved in positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of phosphorylation. Predicted to be part of TORC2 complex. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 195.9), Adrenal (RPKM 180.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (57539279..57631291)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (55811877..55903893)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (56013898..56105818)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
Title: Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
upregulation of miR-424 inhibited Rictor through Akt signaling in renal tissue of diabetic nephropathy rats and high-glucose-treated human glomerular mesangial cells.
Title: Upregulation of microRNA-424 relieved diabetic nephropathy by targeting Rictor through mTOR Complex2/Protein Kinase B signaling.
Study examined mTOR variables, with attention to mTORC2 (Rictor), in Alzheimer's disease (AD) brain samples and in two mouse models, and made comparisons with results from cell- and in vitro-based experiments where Abeta is either expressed or peptide added. Authors conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD.
Title: mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.
Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis.
Title: Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.
These data provide a novel mechanistic link of Nox4-dependent activation of mTORC2 via the energy sensor AMP-activated protein kinase to increased proliferation and survival of PAVSMCs in pulmonary artery hypertension.
Title: Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.
Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction
Title: Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network.

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General gene information

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Markers

AU028259 (e-PCR)
- UniSTS:112500

AU027953 (e-PCR)
- UniSTS:112803

AU026056 (e-PCR)
- UniSTS:114656

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in embryo development ending in birth or egg hatching	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rapamycin-insensitive companion of mTOR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433124.1 → NP_001420053.1 rapamycin-insensitive companion of mTOR isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001433125.1 → NP_001420054.1 rapamycin-insensitive companion of mTOR isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_001433126.1 → NP_001420055.1 rapamycin-insensitive companion of mTOR isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

57539279..57631291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103527.1 → XP_038959455.1 rapamycin-insensitive companion of mTOR isoform X1

UniProtKB/TrEMBL

A0A8I5ZNG4, F1M4J0

Related

ENSRNOP00000079615.1, ENSRNOT00000109110.2

Conserved Domains (5) summary

pfam14663
Location:747 → 853

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:58 → 437

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:1085 → 1188

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:637 → 740

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:922 → 991

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
XM_008760807.2 → XP_008759029.2 rapamycin-insensitive companion of mTOR isoform X3

Related

ENSRNOP00000030782.7, ENSRNOT00000029565.8

Conserved Domains (5) summary

pfam14663
Location:747 → 853

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:58 → 437

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:1085 → 1188

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:637 → 740

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:922 → 991

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
XM_063282846.1 → XP_063138916.1 rapamycin-insensitive companion of mTOR isoform X2
XM_039103528.1 → XP_038959456.1 rapamycin-insensitive companion of mTOR isoform X4

Conserved Domains (5) summary

pfam14663
Location:747 → 853

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:58 → 437

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14665
Location:1085 → 1188

RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site

pfam14666
Location:637 → 740

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:922 → 991

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5