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    Gpr37 G protein-coupled receptor 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117549, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpr37provided by RGD
    Official Full Name
    G protein-coupled receptor 37provided by RGD
    Primary source
    RGD:619848
    See related
    EnsemblRapid:ENSRNOG00000002524 AllianceGenome:RGD:619848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ednrbl
    Summary
    Predicted to enable several functions, including G protein-coupled receptor activity; Hsp70 protein binding activity; and PDZ domain binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to reactive oxygen species; and dendrite development. Predicted to act upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of receptor complex and ubiquitin ligase complex. Predicted to be active in cell surface; plasma membrane; and synapse. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 169.0), Kidney (RPKM 24.1) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Gpr37 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (55104355..55126420, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (54138860..54160927, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51822163..51844228, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene SUV39H2 histone lysine methyltransferase, pseudogene 1 Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA Neighboring gene protection of telomeres 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105347

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity  
    enables G protein-coupled peptide receptor activity  
    enables Hsp70 protein binding  
    enables PDZ domain binding  
    enables heat shock protein binding  
    enables neuropeptide binding  
    enables neuropeptide receptor activity  
    enables peptide binding  
    enables prosaposin receptor activity  
    enables prosaposin receptor activity  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in cell surface  
    located_in cytoplasm  
    located_in dendrite  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    part_of receptor complex  
    is_active_in synapse  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    prosaposin receptor GPR37
    Names
    G protein-coupled receptor 37 (endothelin receptor type B-like)
    G-protein coupled receptor CNS1
    probable G-protein coupled receptor 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057201.2NP_476549.1  prosaposin receptor GPR37 precursor

      See identical proteins and their annotated locations for NP_476549.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9QYC6
      UniProtKB/TrEMBL
      A6IE96
      Related
      ENSRNOP00000003593.4, ENSRNOT00000003593.8
      Conserved Domains (1) summary
      pfam00001
      Location:268538
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      55104355..55126420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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