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    Ankle2 ankyrin repeat and LEM domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankle2provided by RGD
    Official Full Name
    ankyrin repeat and LEM domain containing 2provided by RGD
    Primary source
    RGD:1310191
    See related
    EnsemblRapid:ENSRNOG00000060144 AllianceGenome:RGD:1310191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-034; RGD1310191
    Summary
    Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 178.0), Lung (RPKM 162.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankle2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (52077863..52110775, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (46418142..46451304, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (52475862..52507126, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene peroxisomal membrane protein 2 Neighboring gene PGAM family member 5, mitochondrial serine/threonine protein phosphatase Neighboring gene golgin A3 Neighboring gene uncharacterized LOC134481217 Neighboring gene checkpoint with forkhead and ring finger domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Yamamoto S, et al. Cell, 2014 Sep 25. PMID 25259927, Free PMC Article
    2. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Asencio C, et al. Cell, 2012 Jul 6. PMID 22770216
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic nuclear membrane reassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and LEM domain-containing protein 2
    Names
    LEM domain-containing protein 4
    liver regeneration-related protein LRRG057

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393843.2 → NP_001380772.1  ankyrin repeat and LEM domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      F1LMJ0, F1M1M8, Q7TP65
      Related
      ENSRNOP00000095784.1, ENSRNOT00000101492.2
      Conserved Domains (4) summary
      COG5236
      Location:37 → 184
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd12944
      Location:74 → 116
      LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)
      sd00045
      Location:419 → 452
      ANK; ANK repeat [structural motif]
      cl39094
      Location:384 → 458
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      52077863..52110775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769343.4 → XP_008767565.3  ankyrin repeat and LEM domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANV5
      Related
      ENSRNOP00000107770.1, ENSRNOT00000130998.1
      Conserved Domains (5) summary
      COG5236
      Location:171 → 318
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd12944
      Location:208 → 250
      LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)
      sd00045
      Location:552 → 585
      ANK; ANK repeat [structural motif]
      pfam01693
      Location:360 → 391
      Cauli_VI; Caulimovirus viroplasmin
      cl39094
      Location:517 → 591
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063271551.1 → XP_063127621.1  ankyrin repeat and LEM domain-containing protein 2 isoform X2

    RNA

    1. XR_005491651.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047901.1: Suppressed sequence

      Description
      NM_001047901.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TP65.2 GenPept UniProtKB/Swiss-Prot:Q7TP65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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