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    Cga glycoprotein hormones, alpha polypeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116700, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cgaprovided by RGD
    Official Full Name
    glycoprotein hormones, alpha polypeptideprovided by RGD
    Primary source
    RGD:620436
    See related
    AllianceGenome:RGD:620436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpa1
    Summary
    Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; and thyroid hormone generation. Predicted to act upstream of or within several processes, including gonadotropin secretion; negative regulation of organ growth; and thyroid gland development. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1.3), Uterus (RPKM 0.4) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cga in Genome Data Viewer
    Location:
    5q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (54283109..54295464)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (49486915..49499192)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (50362491..50393368)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486924 Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene ribosomal protein L23a, pseudogene 17 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7, pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables follicle-stimulating hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables follicle-stimulating hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables follicle-stimulating hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within cellular response to hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of steroid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of follicle-stimulating hormone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of follicle-stimulating hormone complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of follicle-stimulating hormone complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of pituitary gonadotropin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycoprotein hormones alpha chain
    Names
    FSH-alpha
    LSH-alpha
    TSH-alpha
    anterior pituitary glycoprotein hormones common subunit alpha
    follicle-stimulating hormone alpha chain
    follitropin alpha chain
    glycoprotein hormone alpha subunit
    glycoprotein hormones, alpha subunit
    luteinizing hormone alpha chain
    lutropin alpha chain
    pituitary hormone alpha subunit
    thyroid-stimulating hormone alpha chain
    thyrotropin alpha chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053918.3NP_446370.3  glycoprotein hormones alpha chain precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P11962, P70516
      UniProtKB/TrEMBL
      A0A0F7RQ24, Q6P509

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      54283109..54295464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287073.1XP_063143143.1  glycoprotein hormones alpha chain isoform X1

      UniProtKB/Swiss-Prot
      P11962, P70516
      UniProtKB/TrEMBL
      A0A0F7RQ24, Q6P509
    2. XM_063287072.1XP_063143142.1  glycoprotein hormones alpha chain isoform X1

      UniProtKB/Swiss-Prot
      P11962, P70516
      UniProtKB/TrEMBL
      A0A0F7RQ24, Q6P509