Prokr2 prokineticin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prokr2provided by RGD
Official Full Name: prokineticin receptor 2provided by RGD
Primary source: RGD:708445
See related: EnsemblRapid:ENSRNOG00000082181 AllianceGenome:RGD:708445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr73l1
Summary: Enables G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and circadian rhythm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 11.1), Spleen (RPKM 2.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (140077629..140092327, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (119624738..119639442, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (125006180..125021020, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified a prokineticin receptor 2 (PKR2) splice variant, which lacking the second exon gives rise to a protein comprising only four transmembrane elements, denominated TM 4-7.
Title: Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease.
PK2 increases the activity of acid-sensing ion channels via the PK2 receptor and protein kinase C-dependent signal pathways in rat primary sensory neurons.
Title: Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons.
The results of this study suggested an intrinsic PK2 neurotransmission and functionally distinct roles for PKR2-expressing neurons in the SCN.
Title: Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prokineticin receptor 2

Names: G protein-coupled receptor 73-like 1; G protein-coupled receptor I5E; PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138978.2 → NP_620434.2 prokineticin receptor 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8R415

UniProtKB/TrEMBL

A6HQG2, G3V8W3

Related

ENSRNOP00000105365.1, ENSRNOT00000170624.1

Conserved Domains (1) summary

cd15204
Location:92 → 382

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

140077629..140092327 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104229.2 → XP_038960157.1 prokineticin receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q8R415

UniProtKB/TrEMBL

A6HQG2, G3V8W3

Conserved Domains (1) summary

cd15204
Location:92 → 382

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors