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    Ptgds prostaglandin D2 synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25526, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptgdsprovided by RGD
    Official Full Name
    prostaglandin D2 synthaseprovided by RGD
    Primary source
    RGD:3433
    See related
    EnsemblRapid:ENSRNOG00000015550 AllianceGenome:RGD:3433
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PH2DISO
    Summary
    Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and response to glucocorticoid. Located in Golgi apparatus and extracellular space. Biomarker of sensorineural hearing loss and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 3126.9) See more
    Orthologs
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    Genomic context

    See Ptgds in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28680044..28682978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8281899..8284833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2686125..2689059, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 3 Neighboring gene PAXX, non-homologous end joining factor Neighboring gene small nucleolar RNA SNORA48 Neighboring gene lipocalin 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid binding  
    enables prostaglandin-D synthase activity PubMed 
    enables prostaglandin-D synthase activity  
    enables retinoid binding PubMed 
    enables retinoid binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in extracellular region PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in nuclear envelope PubMed 
    located_in nuclear membrane  
    located_in perinuclear region of cytoplasm  
    located_in rough endoplasmic reticulum  
    located_in rough endoplasmic reticulum  

    General protein information

    Preferred Names
    prostaglandin-H2 D-isomerase
    Names
    PGD2 synthase
    PGDS
    PGDS2
    Prostaglandin D synthase
    glutathione-independent PGD synthase
    glutathione-independent PGD synthetase
    lipocalin-type prostaglandin-D synthase
    prostaglandin D2 synthase (brain)
    NP_037147.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013015.2NP_037147.1  prostaglandin-H2 D-isomerase precursor

      See identical proteins and their annotated locations for NP_037147.1

      Status: PROVISIONAL

      Source sequence(s)
      J04488
      UniProtKB/Swiss-Prot
      P22057
      UniProtKB/TrEMBL
      A6JT70
      Related
      ENSRNOP00000020926.4, ENSRNOT00000020926.7
      Conserved Domains (1) summary
      cl10502
      Location:30188
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28680044..28682978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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