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    NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]

    Gene ID: 7182, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NR2C2provided by HGNC
    Official Full Name
    nuclear receptor subfamily 2 group C member 2provided by HGNC
    Primary source
    HGNC:HGNC:7972
    See related
    Ensembl:ENSG00000177463 MIM:601426; AllianceGenome:HGNC:7972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR4; TAK1
    Summary
    This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NR2C2 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14947583..15049273)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14950033..15051696)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14989090..15090780)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14845672-14846414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14852491-14852991 Neighboring gene long intergenic non-protein coding RNA 2011 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14855464-14855666 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene Sharpr-MPRA regulatory region 8692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14905091-14905672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14920327-14920828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14941355-14942238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14942239-14943121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14955453-14956275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14956276-14957097 Neighboring gene uncharacterized LOC105376963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14962633-14963132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14963648-14964847 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14965692-14965871 Neighboring gene Sharpr-MPRA regulatory region 15385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14988241-14988930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14989619-14990306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14990307-14990994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19523 Neighboring gene FGD5 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15066535-15067034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19525 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14100 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15139860-15140724 Neighboring gene rabenosyn, RAB effector Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:15149813-15150312 Neighboring gene ribosomal protein S24 pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AMD-associated genes encoding stress-activated MAPK pathway constituents are identified by interval-based enrichment analysis. SanGiovanni JP, et al. PLoS One, 2013. PMID 23940728, Free PMC Article
    2. Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes. O'Geen H, et al. BMC Genomics, 2010 Dec 2. PMID 21126370, Free PMC Article
    3. [Transforming growth factor-β-activated kinase 1 and pathological myocardial hypertrophy]. Li Y, et al. Sheng Li Xue Bao, 2020 Aug 25. PMID 32820312
    4. Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity. Chen D, et al. Cancer Lett, 2020 Dec 28. PMID 32768524
    5. TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation. Liang L, et al. Cell Signal, 2013 Jan. PMID 22981905, Free PMC Article

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
      Title: Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
    2. TR4 worsen urosepsis by regulating GSDMD.
      Title: TR4 worsen urosepsis by regulating GSDMD.
    3. Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
      Title: Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
    4. HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
      Title: HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
    5. Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
      Title: Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
    6. Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
      Title: Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
    7. The stabilization of yes-associated protein by TGFbeta-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
      Title: The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
    8. Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
      Title: Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
    9. Use of miR145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
      Title: Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
    10. LncRNA H19 aggravates TNF-alpha-induced inflammatory injury via TAK1 pathway in MH7A cells.
      Title: LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells.
    Submit: New GeneRIF Correction See all GeneRIFs (98)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 2 group C member 2
    Names
    Nuclear hormone receptor TR4
    orphan nuclear receptor TAK1
    orphan nuclear receptor TR4
    orphan receptor TR4
    testicular nuclear receptor 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291694.2 → NP_001278623.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      See identical proteins and their annotated locations for NP_001278623.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC090937, AC090954, AI986459, AK290590
      Consensus CDS
      CCDS74905.1
      UniProtKB/Swiss-Prot
      A8K3H5, B6ZGT8, P49116, P55092
      UniProtKB/TrEMBL
      Q6PHZ7
      Related
      ENSP00000388387.1, ENST00000425241.6
      Conserved Domains (2) summary
      cd06952
      Location:361 → 582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112 → 198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    2. NM_003298.5 → NP_003289.2  nuclear receptor subfamily 2 group C member 2 isoform 1

      See identical proteins and their annotated locations for NP_003289.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090937, AC090954, AI986459, AK290590, L27586
      Consensus CDS
      CCDS2621.1
      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Related
      ENSP00000320447.6, ENST00000323373.10
      Conserved Domains (2) summary
      cd06952
      Location:380 → 601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131 → 217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      14947583..15049273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448826.1 → XP_047304782.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    2. XM_047448825.1 → XP_047304781.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    3. XM_047448830.1 → XP_047304786.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    4. XM_047448829.1 → XP_047304785.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/TrEMBL
      Q6PHZ7

    5. XM_011534058.4 → XP_011532360.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532360.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    6. XM_047448836.1 → XP_047304792.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7

    7. XM_011534063.4 → XP_011532365.1  nuclear receptor subfamily 2 group C member 2 isoform X3

      See identical proteins and their annotated locations for XP_011532365.1

      Conserved Domains (2) summary
      cd06952
      Location:394 → 615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145 → 231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    8. XM_011534064.4 → XP_011532366.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532366.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380 → 601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131 → 217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    9. XM_047448827.1 → XP_047304783.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    10. XM_011534065.4 → XP_011532367.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532367.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380 → 601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131 → 217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    11. XM_011534061.4 → XP_011532363.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532363.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    12. XM_047448837.1 → XP_047304793.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7

    13. XM_047448832.1 → XP_047304788.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    14. XM_047448838.1 → XP_047304794.1  nuclear receptor subfamily 2 group C member 2 isoform X8

      UniProtKB/TrEMBL
      Q6PHZ7

    15. XM_047448835.1 → XP_047304791.1  nuclear receptor subfamily 2 group C member 2 isoform X6

      UniProtKB/TrEMBL
      Q6PHZ7

    16. XM_011534059.3 → XP_011532361.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532361.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    17. XM_047448831.1 → XP_047304787.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    18. XM_047448828.1 → XP_047304784.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    19. XM_047448824.1 → XP_047304780.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413 → 634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164 → 250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    20. XM_047448834.1 → XP_047304790.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Related
      ENSP00000483059.1, ENST00000617312.4

    21. XM_011534066.4 → XP_011532368.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532368.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380 → 601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131 → 217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    22. XM_047448833.1 → XP_047304789.1  nuclear receptor subfamily 2 group C member 2 isoform X4

      UniProtKB/TrEMBL
      Q6PHZ7

    23. XM_024453739.2 → XP_024309507.1  nuclear receptor subfamily 2 group C member 2 isoform X9

      Conserved Domains (2) summary
      cd06952
      Location:182 → 403
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:1 → 19
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      14950033..15051696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347716.1 → XP_054203691.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    2. XM_054347714.1 → XP_054203689.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    3. XM_054347721.1 → XP_054203696.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    4. XM_054347719.1 → XP_054203694.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/TrEMBL
      Q6PHZ7

    5. XM_054347711.1 → XP_054203686.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    6. XM_054347728.1 → XP_054203703.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7

    7. XM_054347720.1 → XP_054203695.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    8. XM_054347724.1 → XP_054203699.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7

    9. XM_054347717.1 → XP_054203692.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    10. XM_054347725.1 → XP_054203700.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7

    11. XM_054347713.1 → XP_054203688.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    12. XM_054347729.1 → XP_054203704.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7

    13. XM_054347723.1 → XP_054203698.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    14. XM_054347730.1 → XP_054203705.1  nuclear receptor subfamily 2 group C member 2 isoform X8

      UniProtKB/TrEMBL
      Q6PHZ7

    15. XM_054347727.1 → XP_054203702.1  nuclear receptor subfamily 2 group C member 2 isoform X6

      UniProtKB/TrEMBL
      Q6PHZ7

    16. XM_054347715.1 → XP_054203690.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    17. XM_054347722.1 → XP_054203697.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    18. XM_054347718.1 → XP_054203693.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    19. XM_054347712.1 → XP_054203687.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7

    20. XM_054347726.1 → XP_054203701.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7

    21. XM_054347731.1 → XP_054203706.1  nuclear receptor subfamily 2 group C member 2 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49116.1 GenPept UniProtKB/Swiss-Prot:P49116

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