U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    LUC7L3 LUC7 like 3 pre-mRNA splicing factor [ Homo sapiens (human) ]

    Gene ID: 51747, updated on 10-Dec-2024

    Summary

    Official Symbol
    LUC7L3provided by HGNC
    Official Full Name
    LUC7 like 3 pre-mRNA splicing factorprovided by HGNC
    Primary source
    HGNC:HGNC:24309
    See related
    Ensembl:ENSG00000108848 MIM:609434; AllianceGenome:HGNC:24309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18
    Summary
    This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LUC7L3 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50719603..50756219)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51586802..51623382)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48796964..48833580)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8706 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:48715992-48717191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48717641-48718411 Neighboring gene ATP binding cassette subfamily C member 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:48738547-48739746 Neighboring gene Sharpr-MPRA regulatory region 5804 Neighboring gene ABCC3 (B) eExon liver enhancer Neighboring gene Sharpr-MPRA regulatory region 2031 Neighboring gene ankyrin repeat domain 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48802297-48802796 Neighboring gene Sharpr-MPRA regulatory region 5668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12389 Neighboring gene ANKRD40 C-terminal like Neighboring gene microRNA 8059

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables RNA binding PubMed 
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing PubMed 
    involved_in mRNA splice site recognition  
    Component Evidence Code Pubs
    part_of U1 snRNP  
    part_of U2-type prespliceosome  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    luc7-like protein 3
    Names
    CRE-associated protein 1
    LUC7-like 3
    cAMP regulatory element-associated protein 1
    cisplatin resistance-associated-overexpressed protein
    okadaic acid-inducible phosphoprotein OA48-18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330330.2NP_001317259.1  luc7-like protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC005921, AK225980, BC047043, DA218563
      Consensus CDS
      CCDS82158.1
      UniProtKB/TrEMBL
      J3KPP4
      Related
      ENSP00000376919.2, ENST00000393227.6
      Conserved Domains (1) summary
      pfam03194
      Location:4246
      LUC7; LUC7 N_terminus
    2. NM_006107.4NP_006098.2  luc7-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_006098.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal region in the 3' UTR, as compared to variant 1.
      Source sequence(s)
      AC005921, AK023672, CN271700
      Consensus CDS
      CCDS11573.1
      UniProtKB/Swiss-Prot
      B3KN54, D3DTY1, O95232, Q6PHR9, Q9NUY0, Q9P2S7
      UniProtKB/TrEMBL
      A8K3C5
      Related
      ENSP00000240304.1, ENST00000240304.5
      Conserved Domains (1) summary
      pfam03194
      Location:4246
      LUC7; LUC7 N_terminus
    3. NM_016424.5NP_057508.2  luc7-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_057508.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC005921, AK290540, BC047043, CN271700, DA231851
      Consensus CDS
      CCDS11573.1
      UniProtKB/Swiss-Prot
      B3KN54, D3DTY1, O95232, Q6PHR9, Q9NUY0, Q9P2S7
      UniProtKB/TrEMBL
      A8K3C5
      Related
      ENSP00000425092.1, ENST00000505658.6
      Conserved Domains (1) summary
      pfam03194
      Location:4246
      LUC7; LUC7 N_terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      50719603..50756219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257452.2XP_005257509.1  luc7-like protein 3 isoform X2

      See identical proteins and their annotated locations for XP_005257509.1

      UniProtKB/TrEMBL
      A8K3C5
      Conserved Domains (1) summary
      pfam03194
      Location:4246
      LUC7; LUC7 N_terminus
    2. XM_005257449.3XP_005257506.1  luc7-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005257506.1

      UniProtKB/TrEMBL
      A8K3C5
      Conserved Domains (1) summary
      pfam03194
      Location:4246
      LUC7; LUC7 N_terminus
    3. XM_047436247.1XP_047292203.1  luc7-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K3C5
    4. XM_006721943.3XP_006722006.1  luc7-like protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006722006.1

      Conserved Domains (1) summary
      cl27291
      Location:4170
      LUC7; LUC7 N_terminus
    5. XM_047436248.1XP_047292204.1  luc7-like protein 3 isoform X4

    6. XM_047436249.1XP_047292205.1  luc7-like protein 3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      51586802..51623382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316416.1XP_054172391.1  luc7-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K3C5
    2. XM_054316415.1XP_054172390.1  luc7-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K3C5
    3. XM_054316417.1XP_054172392.1  luc7-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K3C5
    4. XM_054316419.1XP_054172394.1  luc7-like protein 3 isoform X4

    5. XM_054316418.1XP_054172393.1  luc7-like protein 3 isoform X4

    6. XM_054316420.1XP_054172395.1  luc7-like protein 3 isoform X4

    External link. Please review our privacy policy.