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    APRG1 APRG1 tumor suppressor candidate [ Homo sapiens (human) ]

    Gene ID: 339883, updated on 10-Dec-2024

    Summary

    Official Symbol
    APRG1provided by HGNC
    Official Full Name
    APRG1 tumor suppressor candidateprovided by HGNC
    Primary source
    HGNC:HGNC:24082
    See related
    Ensembl:ENSG00000198590 MIM:611429; AllianceGenome:HGNC:24082
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C3orf35
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See APRG1 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (37381077..37435497)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (37382609..37437035)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (37422568..37476988)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene golgin A4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:37339657-37340856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:37343371-37344032 Neighboring gene transcription elongation factor A1 pseudogene 2 Neighboring gene MPRA-validated peak4611 silencer Neighboring gene RNA, 5S ribosomal pseudogene 129 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:37485219-37485403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516063-37516575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37516576-37517087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37539704-37540204 Neighboring gene integrin subunit alpha 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37579429-37579930 Neighboring gene RNA, U7 small nuclear 73 pseudogene Neighboring gene MPRA-validated peak4612 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:37734983-37735674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:37783057-37783865 Neighboring gene NANOG hESC enhancer GRCh37_chr3:37784268-37784945 Neighboring gene ribosomal protein L21 pseudogene 135

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    General gene information

    Other Names

    • AP20 region protein 1
    • AP20 region protein1

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_126512.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) contains an additional internal exon and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant B, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC092055, AJ493599, AJ493601
      Related
      ENST00000332506.7
    2. NR_126513.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) lacks two internal exons and uses an alternate splice site in the 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
      Source sequence(s)
      AC092055, AJ493601
    3. NR_126514.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) lacks two internal exons, compared to variant B. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant B.
      Source sequence(s)
      AC092055, AJ493600, AJ493602
    4. NR_126515.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (F) lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant B. This variant is represented as non-coding because it lacks the entire coding region found in variant B.
      Source sequence(s)
      AJ493601, AJ493604
    5. NR_171173.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136290
      Related
      ENST00000665000.1
    6. NR_171174.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136290

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      37381077..37435497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791771.1 Reference GRCh38.p14 PATCHES

      Range
      4677..5336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      37382609..37437035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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