U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    WDFY1 WD repeat and FYVE domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 57590, updated on 9-Dec-2024

    Summary

    Official Symbol
    WDFY1provided by HGNC
    Official Full Name
    WD repeat and FYVE domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:20451
    See related
    Ensembl:ENSG00000085449 MIM:618080; AllianceGenome:HGNC:20451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WDF1; FENS1; FENS-1; ZFYVE17
    Summary
    The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 20.9), thyroid (RPKM 16.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WDFY1 in Genome Data Viewer
    Location:
    2q36.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (223875348..223945335, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (224358556..224428591, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (224740065..224810052, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17172 Neighboring gene adaptor related protein complex 1 subunit sigma 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17175 Neighboring gene uncharacterized LOC124907988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:224746345-224746846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:224746847-224747346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17181 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:224786671-224787171 Neighboring gene general transcription factor IIIA pseudogene 3 Neighboring gene uncharacterized LOC124907989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17184 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene serpin family E member 2 Neighboring gene uncharacterized LOC124907990 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:224874015-224875214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:224879805-224880304

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat and FYVE domain-containing protein 1
    Names
    FYVE domain-containing protein localized to endosomes 1
    WD40- and FYVE domain-containing protein 1
    phosphoinositide-binding protein SR1
    zinc finger FYVE domain-containing protein 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020830.5NP_065881.1  WD repeat and FYVE domain-containing protein 1

      See identical proteins and their annotated locations for NP_065881.1

      Status: REVIEWED

      Source sequence(s)
      AC073641, AJ310568, AK022888, AK023415, BU682241
      Consensus CDS
      CCDS33387.1
      UniProtKB/Swiss-Prot
      Q53S17, Q8IWB7, Q9H9D5, Q9P2B3
      UniProtKB/TrEMBL
      E7EML6, Q9H8N9
      Related
      ENSP00000233055.4, ENST00000233055.9
      Conserved Domains (3) summary
      cd15756
      Location:279354
      FYVE_WDFY1; FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar proteins
      sd00039
      Location:117154
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:16272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      223875348..223945335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      224358556..224428591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)