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    C11orf71 chromosome 11 open reading frame 71 [ Homo sapiens (human) ]

    Gene ID: 54494, updated on 10-Dec-2024

    Summary

    Official Symbol
    C11orf71provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 71provided by HGNC
    Primary source
    HGNC:HGNC:25937
    See related
    Ensembl:ENSG00000180425 AllianceGenome:HGNC:25937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URLC7
    Expression
    Broad expression in testis (RPKM 41.5), kidney (RPKM 6.0) and 18 other tissues See more
    Orthologs
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    Genomic context

    See C11orf71 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114391443..114400511, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114401848..114410930, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114262165..114271233, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114128337-114128865 Neighboring gene nicotinamide N-methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:114166597-114167097 Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:114270475-114271017 and GRCh37_chr11:114271018-114271560 Neighboring gene RNA binding motif protein 7 Neighboring gene RNA exonuclease 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1241 screens)

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    uncharacterized protein C11orf71
    Names
    up-regulated in lung cancer 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271562.2NP_001258491.1  uncharacterized protein C11orf71 isoform 1

      See identical proteins and their annotated locations for NP_001258491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK000017, AP002373, HY013971
      Consensus CDS
      CCDS76479.1
      UniProtKB/Swiss-Prot
      Q6IAD3, Q6IPW1, Q9NXX1
      UniProtKB/TrEMBL
      A0A0A8K8C2
      Related
      ENSP00000492536.1, ENST00000623205.2
      Conserved Domains (1) summary
      pfam15747
      Location:1112
      DUF4687; Domain of unknown function (DUF4687)
    2. NM_019021.4NP_061894.2  uncharacterized protein C11orf71 isoform 2

      See identical proteins and their annotated locations for NP_061894.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon structure in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AP002373, BC071695, HY013971
      Consensus CDS
      CCDS8369.2
      UniProtKB/Swiss-Prot
      Q6IPW1
      Related
      ENSP00000325508.4, ENST00000325636.8
      Conserved Domains (1) summary
      pfam15747
      Location:1112
      DUF4687; Domain of unknown function (DUF4687)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      114391443..114400511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      114401848..114410930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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