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    RNF122 ring finger protein 122 [ Homo sapiens (human) ]

    Gene ID: 79845, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNF122provided by HGNC
    Official Full Name
    ring finger protein 122provided by HGNC
    Primary source
    HGNC:HGNC:21147
    See related
    Ensembl:ENSG00000133874 MIM:620523; AllianceGenome:HGNC:21147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in gall bladder (RPKM 7.2), adrenal (RPKM 6.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF122 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (33547754..33567128, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (33819016..33838397, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33405272..33424646, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900261 Neighboring gene ribosomal protein L10 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19103 Neighboring gene RNA, 7SL, cytoplasmic 621, pseudogene Neighboring gene dual specificity phosphatase 26 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:33455207-33455707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis. Xiao Q, et al. CNS Neurosci Ther, 2024 Sep. PMID 39218810, Free PMC Article
    2. [Cloning, expression and subcellular localization of a novel human gene-RNF122]. Wang L, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2006 Jun 18. PMID 16778963
    3. Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder. Garcia-Martínez I, et al. Sci Rep, 2017 Jul 14. PMID 28710364, Free PMC Article
    4. Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification. Koyama K, et al. Genomics, 1995 Mar 20. PMID 7601449
    5. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Wang W, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27506794, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis.
      Title: RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis.
    2. Findings indicate genetic association between E3 ubiquitin ligase RNF122 and Attention Deficit Disorders with Hyperactivity (ADHD).
      Title: Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12526, MGC126622

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 122

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024787.3 → NP_079063.2  RING finger protein 122

      See identical proteins and their annotated locations for NP_079063.2

      Status: REVIEWED

      Source sequence(s)
      AC013603, BC093884, DA610129, DA904646
      Consensus CDS
      CCDS6091.1
      UniProtKB/Swiss-Prot
      Q52LK3, Q9H9V4
      Related
      ENSP00000256257.1, ENST00000256257.2
      Conserved Domains (1) summary
      cd16469
      Location:91 → 137
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      33547754..33567128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013846.2 → XP_016869335.1  RING finger protein 122 isoform X1

      Conserved Domains (1) summary
      pfam13639
      Location:68 → 109
      zf-RING_2; Ring finger domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      33819016..33838397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361246.1 → XP_054217221.1  RING finger protein 122 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H9V4.2 GenPept UniProtKB/Swiss-Prot:Q9H9V4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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