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    DCN decorin [ Homo sapiens (human) ]

    Gene ID: 1634, updated on 10-Dec-2024

    Summary

    Official Symbol
    DCNprovided by HGNC
    Official Full Name
    decorinprovided by HGNC
    Primary source
    HGNC:HGNC:2705
    See related
    Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DCN in Genome Data Viewer
    Location:
    12q21.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (91140484..91182817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (91117966..91160293, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (91534261..91576594, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratocan Neighboring gene VISTA enhancer hs2540 Neighboring gene lumican Neighboring gene uncharacterized LOC124903075 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:91666219-91666772 Neighboring gene uncharacterized LOC105369896 Neighboring gene uncharacterized LOC107984544

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (8 hits/1271 screens)

    Associated conditions

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    decorin
    Names
    bone proteoglycan II
    dermatan sulphate proteoglycans II
    proteoglycan core protein
    small leucine-rich protein 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011672.2 RefSeqGene

      Range
      5000..47333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001920.5 → NP_001911.1  decorin isoform a preproprotein

      See identical proteins and their annotated locations for NP_001911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A1) represents the longest transcript and encodes the longest isoform. Both variants A1 and A2 encode the same isoform (a).
      Source sequence(s)
      AC007115, AW444736, BM672011, BX094949, BX571756, CD689331
      Consensus CDS
      CCDS9039.1
      UniProtKB/Swiss-Prot
      P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
      UniProtKB/TrEMBL
      Q6FH10
      Related
      ENSP00000052754.5, ENST00000052754.10
      Conserved Domains (3) summary
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:54 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cl26018
      Location:70 → 298
      NEL; C-terminal novel E3 ligase, LRR-interacting
    2. NM_133503.4 → NP_598010.1  decorin isoform a preproprotein

      See identical proteins and their annotated locations for NP_598010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A2) differs in the 5' UTR compared to variant A1. Both variants A1 and A2 encode the same isoform (a).
      Source sequence(s)
      AC007115, AW444736, BM672011, BX094949, BX571756
      Consensus CDS
      CCDS9039.1
      UniProtKB/Swiss-Prot
      P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
      UniProtKB/TrEMBL
      Q6FH10
      Conserved Domains (3) summary
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:54 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      cl26018
      Location:70 → 298
      NEL; C-terminal novel E3 ligase, LRR-interacting
    3. NM_133504.3 → NP_598011.1  decorin isoform b precursor

      See identical proteins and their annotated locations for NP_598011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138301, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9040.1
      UniProtKB/Swiss-Prot
      P07585
      UniProtKB/TrEMBL
      Q6FH10
      Related
      ENSP00000413723.2, ENST00000420120.6
      Conserved Domains (4) summary
      smart00013
      Location:54 → 77
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:70 → 92
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:112 → 172
      LRR_8; Leucine rich repeat
      cl26793
      Location:70 → 196
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. NM_133505.3 → NP_598012.1  decorin isoform c precursor

      See identical proteins and their annotated locations for NP_598012.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR and lacks three alternate exons in the coding region compared to variant A1. The encoded isoform (c) is shorter than isoform a. This isoform (c) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138302, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9041.1
      UniProtKB/TrEMBL
      F8VNV6
      Related
      ENSP00000401021.1, ENST00000425043.5
      Conserved Domains (3) summary
      smart00013
      Location:54 → 76
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:76 → 99
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:74 → 134
      LRR_8; Leucine rich repeat
    5. NM_133506.3 → NP_598013.1  decorin isoform d precursor

      See identical proteins and their annotated locations for NP_598013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) differs in the 5' UTR and lacks four alternate exons in the coding region compared to variant A1. The encoded isoform (d) is shorter than isoform a. This isoform (d) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138303, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS9042.1
      UniProtKB/TrEMBL
      A0A0S2Z3L8
      Related
      ENSP00000399815.2, ENST00000441303.6
      Conserved Domains (3) summary
      smart00013
      Location:54 → 85
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:62 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:84 → 125
      LRR_8; Leucine rich repeat
    6. NM_133507.3 → NP_598014.1  decorin isoform e precursor

      See identical proteins and their annotated locations for NP_598014.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) differs in the 5' UTR and lacks five alternate exons in the coding region compared to variant A1. The encoded isoform (e) is shorter than isoform a. This isoform (e) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC007115, AF138304, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
      Consensus CDS
      CCDS44951.1
      UniProtKB/TrEMBL
      A0A7I2PRI8
      Related
      ENSP00000398514.2, ENST00000456569.2
      Conserved Domains (1) summary
      cl02423
      Location:54 → 71
      LRRNT; Leucine rich repeat N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      91140484..91182817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      91117966..91160293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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