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    RND1 Rho family GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 27289, updated on 10-Dec-2024

    Summary

    Official Symbol
    RND1provided by HGNC
    Official Full Name
    Rho family GTPase 1provided by HGNC
    Primary source
    HGNC:HGNC:18314
    See related
    Ensembl:ENSG00000172602 MIM:609038; AllianceGenome:HGNC:18314
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHS; RHO6; RHOS
    Summary
    This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in liver (RPKM 28.4), brain (RPKM 15.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RND1 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48857145..48865870, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48819339..48828069, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49250928..49259653, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49208339-49208840 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49208841-49209340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4413 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 3 Neighboring gene DEAD-box helicase 23 Neighboring gene uncharacterized LOC105369755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6291 Neighboring gene Sharpr-MPRA regulatory region 11040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6294 Neighboring gene RNA, U6 small nuclear 600, pseudogene Neighboring gene MPRA-validated peak1724 silencer Neighboring gene ribosomal protein L32 pseudogene 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (39 hits/1258 screens)

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Rho family GTPase 1 (RND1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ42294

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables signaling receptor binding PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in adherens junction PubMed 
    is_active_in cytosol  
    located_in intracellular membrane-bounded organelle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    rho-related GTP-binding protein Rho6
    Names
    ras homolog gene family, member S

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014470.4 → NP_055285.1  rho-related GTP-binding protein Rho6 precursor

      See identical proteins and their annotated locations for NP_055285.1

      Status: REVIEWED

      Source sequence(s)
      AL359573, BC026356, N79562
      Consensus CDS
      CCDS8771.1
      UniProtKB/Swiss-Prot
      A8K9P7, Q92730
      Related
      ENSP00000308461.5, ENST00000309739.6
      Conserved Domains (1) summary
      cd04174
      Location:1 → 232
      Rnd1_Rho6; Rnd1/Rho6 GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48857145..48865870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48819339..48828069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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