SRSF3 serine and arginine rich splicing factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRSF3provided by HGNC
Official Full Name: serine and arginine rich splicing factor 3provided by HGNC
Primary source: HGNC:HGNC:10785
See related: Ensembl:ENSG00000112081 MIM:603364; AllianceGenome:HGNC:10785
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SFRS3; SRp20
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.31-p21.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (36594362..36605600)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (36415006..36426242)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (36562139..36573377)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
Title: SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
Title: Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
Title: Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
Title: Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
Title: An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
Title: Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
Title: SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
Title: Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.
Title: Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	SRSF3 (serine/arginine-rich splicing factor 3) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH18481 (e-PCR)
- UniSTS:40544

WI-11748 (e-PCR)
- UniSTS:71523

RH78275 (e-PCR)
- UniSTS:64622

STS-L10838 (e-PCR)
- UniSTS:3193

SFRS3_1875 (e-PCR)
- UniSTS:280994

ECD07635 (e-PCR)
- UniSTS:288686

D6S1788 (e-PCR)
- UniSTS:9445

STS-H70468 (e-PCR)
- UniSTS:67307

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
NOT enables pre-mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables primary miRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA sequence-specific adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in mRNA cis splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 3

Names: epididymis secretory sperm binding protein; pre-mRNA splicing factor SRp20; pre-mRNA-splicing factor SRP20; splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich, 20-kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003017.5 → NP_003008.1 serine/arginine-rich splicing factor 3

See identical proteins and their annotated locations for NP_003008.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the protein-coding variant.

Source sequence(s)

Z85986

Consensus CDS

CCDS4823.1

UniProtKB/Swiss-Prot

B4E241, O08831, P23152, P84103, Q5R3K0

UniProtKB/TrEMBL

B2R6F3

Related

ENSP00000362820.5, ENST00000373715.11

Conserved Domains (1) summary

cd12645
Location:6 → 86

RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

RNA

NR_036610.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional exon in the 3' UTR compared to variant 1, making this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to be protein-coding.

Source sequence(s)

AF107405, BM833102, DC398250, Z85986