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    PTGFR prostaglandin F receptor [ Homo sapiens (human) ]

    Gene ID: 5737, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PTGFRprovided by HGNC
    Official Full Name
    prostaglandin F receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9600
    See related
    Ensembl:ENSG00000122420 MIM:600563; AllianceGenome:HGNC:9600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP
    Summary
    The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTGFR in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78490974..78540701)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78329334..78379549)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78956659..79006386)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:78702835-78703748 Neighboring gene uncharacterized MGC27382 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:78805687-78806886 Neighboring gene RNA, 5S ribosomal pseudogene 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:78957125-78957657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1237 Neighboring gene interferon induced protein 44 like Neighboring gene interferon induced protein 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Role of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F2alpha receptor (hFP-R) in G-protein coupling control. Pathe-Neuschäfer-Rube A, et al. Biochem J, 2005 May 15. PMID 15651980, Free PMC Article
    2. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. Kunapuli P, et al. J Biol Chem, 1997 Oct 24. PMID 9341156
    3. Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. Betz R, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918852
    4. Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Neuschäfer-Rube F, et al. Biochem J, 2003 Apr 15. PMID 12519077, Free PMC Article
    5. Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. Hay A, et al. Mol Hum Reprod, 2010 Oct. PMID 20519365

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ligand-induced activation and G protein coupling of prostaglandin F2alpha receptor.
      Title: Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor.
    2. Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
      Title: Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
    3. Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/PTGFR and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (PTGFR = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1)
      Title: Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
    4. Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)
      Title: Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.
    5. The genotype frequencies of six SNPs in AFAP1, GMDS and PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE).
      Title: Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.
    6. these results indicated that the actions of AKR1C3 can produce FP receptor ligands whose activation results in carcinoma cell survival in breast cancer.
      Title: 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer.
    7. The results indicated that the rs12731181 G allele of the Prostaglandin F2alpha Receptor Gene was associated with susceptibility to essential hypertension.
      Title: Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.
    8. Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients
      Title: Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.
    9. The SNPs of the PTGFR and MMP-1 genes may determine the latanoprost response in a white European Spanish population.
      Title: Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma.
    10. Angiotensin II type I and prostaglandin F2alpha receptors cooperatively modulate signaling in vascular smooth muscle cells
      Title: Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46203, MGC120498

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prostaglandin F receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin F receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to prostaglandin D stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in parturition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin F2-alpha receptor
    Names
    FP prostanoid receptor
    PGF receptor
    PGF2 alpha receptor
    prostaglandin receptor (2-alpha)
    prostanoid FP receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052997.1 RefSeqGene

      Range
      5001..54728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000959.4 → NP_000950.1  prostaglandin F2-alpha receptor isoform a precursor

      See identical proteins and their annotated locations for NP_000950.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL136324, BC112965
      Consensus CDS
      CCDS686.1
      UniProtKB/Swiss-Prot
      A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4
      Related
      ENSP00000359793.3, ENST00000370757.8
      Conserved Domains (1) summary
      cd15145
      Location:27 → 316
      7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001039585.2 → NP_001034674.1  prostaglandin F2-alpha receptor isoform b precursor

      See identical proteins and their annotated locations for NP_001034674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL136324, BC112965, CD013876
      Consensus CDS
      CCDS30759.1
      UniProtKB/TrEMBL
      F2Z2Z6
      Related
      ENSP00000359792.3, ENST00000370756.3
      Conserved Domains (1) summary
      pfam00001
      Location:44 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      78490974..78540701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426085.1 → XP_047282041.1  prostaglandin F2-alpha receptor isoform X1

      UniProtKB/Swiss-Prot
      A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4

    2. XM_017001873.1 → XP_016857362.1  prostaglandin F2-alpha receptor isoform X2

      UniProtKB/TrEMBL
      F2Z2Z6

    3. XM_047426101.1 → XP_047282057.1  prostaglandin F2-alpha receptor isoform X3

      UniProtKB/TrEMBL
      F2Z2Z6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      78329334..78379549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337809.1 → XP_054193784.1  prostaglandin F2-alpha receptor isoform X1

      UniProtKB/Swiss-Prot
      A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4

    2. XM_054337810.1 → XP_054193785.1  prostaglandin F2-alpha receptor isoform X2

      UniProtKB/TrEMBL
      F2Z2Z6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43088.1 GenPept UniProtKB/Swiss-Prot:P43088

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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