Dcp2 decapping mRNA 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dcp2provided by RGD
Full Name: decapping mRNA 2provided by RGD
Primary source: RGD:1562909
See related: EnsemblRapid:ENSRNOG00000045895 AllianceGenome:RGD:1562909
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562909
Summary: Predicted to enable 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; 5'-3' RNA exonuclease activity; and telomerase RNA binding activity. Predicted to be involved in negative regulation of macromolecule biosynthetic process and regulation of telomerase RNA localization to Cajal body. Predicted to be located in cell junction; cytoplasmic ribonucleoprotein granule; and nucleoplasm. Predicted to be part of RISC complex. Predicted to be active in P-body. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 147.5), Thymus (RPKM 143.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (37001615..37037949)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (36750732..36787067)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (35489274..35671676)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:532335

Dcp2 (e-PCR), detects polymorphism
- UniSTS:532335

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
enables 5'-3' RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
part_of RISC complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: m7GpppN-mRNA hydrolase

Names: DCP2 decapping enzyme homolog; m7GpppN-mRNA hydrolase-like; mRNA-decapping enzyme 2; mRNA-decapping enzyme 2-like

NP_001163940.1

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170469.1 → NP_001163940.1 m7GpppN-mRNA hydrolase

Status: INFERRED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2QC37

Related

ENSRNOP00000068347.3, ENSRNOT00000076060.3

Conserved Domains (2) summary

cd03672
Location:97 → 246

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:12 → 94

DCP2; Dcp2, box A domain