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    Gdf7 growth differentiation factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gdf7provided by RGD
    Official Full Name
    growth differentiation factor 7provided by RGD
    Primary source
    RGD:620105
    See related
    EnsemblRapid:ENSRNOG00000088409 AllianceGenome:RGD:620105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of SMAD protein signal transduction; positive regulation of macromolecule biosynthetic process; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; nervous system development; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GDF7 (growth differentiation factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 82.8), Kidney (RPKM 11.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gdf7 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (36890799..36901783, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (31171495..31182484, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (33496596..33507626, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692595 Neighboring gene lipid droplet associated hydrolase Neighboring gene uncharacterized LOC134479336 Neighboring gene HCLS1 binding protein 3 Neighboring gene uncharacterized LOC120103507 Neighboring gene uncharacterized LOC102550373

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair. Jelinsky SA, et al. J Orthop Res, 2011 Oct. PMID 21469182
    2. Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7. Lo L, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15883363, Free PMC Article
    3. The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation. Settle S, et al. Dev Biol, 2001 Jun 1. PMID 11356025
    4. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. Lee JY, et al. PLoS One, 2011 Mar 11. PMID 21412429, Free PMC Article
    5. The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. Akbar MT, et al. J Biol Chem, 2003 May 30. PMID 12639970

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression regulated during tendon healing
      Title: Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair.
    2. involved in the formation of periodontal ligament
      Title: Gene expression of growth differentiation factors in the developing periodontium of rat molars.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within morphogenesis of an epithelial fold ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tendon cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reproductive structure development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof plate formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spinal cord association neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth/differentiation factor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170350.3 → NP_001163821.1  growth/differentiation factor 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HAL5, F1MAE8
      Conserved Domains (2) summary
      pfam00019
      Location:351 → 448
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:87 → 223
      TGFb_propeptide; TGF-beta propeptide

    2. NM_001399290.2 → NP_001386219.1  growth/differentiation factor 7 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HAL5
      Related
      ENSRNOP00000101233.1, ENSRNOT00000155630.1
      Conserved Domains (2) summary
      cd13766
      Location:358 → 456
      TGF_beta_GDF5_6_7; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins
      cl02928
      Location:87 → 231
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      36890799..36901783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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