Slc45a2 solute carrier family 45, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc45a2provided by RGD
Official Full Name: solute carrier family 45, member 2provided by RGD
Primary source: RGD:1306690
See related: EnsemblRapid:ENSRNOG00000018759 AllianceGenome:RGD:1306690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Matp
Summary: Predicted to enable D-glucose:proton symporter activity and sucrose:proton symporter activity. Predicted to be involved in lysosomal lumen pH elevation and melanin biosynthetic process from tyrosine. Predicted to act upstream of or within developmental pigmentation and sucrose transport. Predicted to be located in melanosome membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism type IV and pigmentation disease. Orthologous to human SLC45A2 (solute carrier family 45 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (61690828..61723437)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (59963599..59996408)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (60966671..60999398)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU029213 (e-PCR)
- UniSTS:111591

AU025511 (e-PCR)
- UniSTS:115191

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables sucrose:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sucrose:proton symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in hexose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in lysosomal lumen pH elevation	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process from tyrosine	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sucrose transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: membrane-associated transporter protein

Names: membrane associated transporter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107653.1 → NP_001101123.1 membrane-associated transporter protein

See identical proteins and their annotated locations for NP_001101123.1

Status: PROVISIONAL

Source sequence(s)

CH474058

UniProtKB/TrEMBL

A6KJS1, D3ZR99

Related

ENSRNOP00000025490.3, ENSRNOT00000025490.6

Conserved Domains (2) summary

pfam13347
Location:36 → 524

MFS_2; MFS/sugar transport protein

cl21472
Location:39 → 231

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...