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    Serpina16 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpina16provided by RGD
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16provided by RGD
    Primary source
    RGD:727888
    See related
    EnsemblRapid:ENSRNOG00000026297 AllianceGenome:RGD:727888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 5.2), Liver (RPKM 0.8) and 3 other tissues See more
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    Genomic context

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    See Serpina16 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128565659..128573037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122800869..122808247, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127544773..127552151, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene serpin family A member 10 Neighboring gene serpin family A member 6 Neighboring gene serpin family A member 1F Neighboring gene serpin family A member 1F like 2 Neighboring gene serpin family A member 1F like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility. Zhou Y, et al. PLoS One, 2008. PMID 19116669, Free PMC Article
    2. Identification and characterization of a new member of serpin family- HongrES1 in rat epididymis. Hu ZH, et al. Cell Res, 2002 Dec. PMID 12528899
    3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HongrES1 as a novel and critical molecule in the regulation of sperm capacitation and male fertility.
      Title: An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16
    Names
    serine proteinase inhibitor HongrES1
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181630.3 → NP_853661.2  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JEP0, G3V8X9, Q7TN19
      Related
      ENSRNOP00000030237.3, ENSRNOT00000035035.6
      Conserved Domains (1) summary
      cd19587
      Location:40 → 406
      serpinA16_HongrES1-like; serpin family A member 16, HongrES1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      128565659..128573037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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