Hsp90aa1 heat shock protein 90 alpha family class A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsp90aa1provided by RGD
Official Full Name: heat shock protein 90 alpha family class A member 1provided by RGD
Primary source: RGD:631409
See related: EnsemblRapid:ENSRNOG00000059714 AllianceGenome:RGD:631409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsp86; Hsp90; Hspca
Summary: Enables several functions, including Rho GDP-dissociation inhibitor binding activity; nucleotide binding activity; and sulfonylurea receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; positive regulation of cardiac muscle contraction; and positive regulation of cell size. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and sperm mitochondrial sheath. Part of protein-containing complex. Biomarker of portal hypertension. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2165.3), Testes (RPKM 1934.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (135523604..135529687, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (129702376..129707907, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (135107262..135112793, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Title: Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling.
Title: HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling.
Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats.
Title: Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats.
Exposure to 2.45 GHz radiofrequency modulates calcitonin-dependent activity and HSP-90 protein in parafollicular cells of rat thyroid gland.
Title: Exposure to 2.45 GHz radiofrequency modulates calcitonin-dependent activity and HSP-90 protein in parafollicular cells of rat thyroid gland.
The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes.
Title: The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes.
Hsp90 is involved in cAMP-induced diffentiation of primary Schwann cells in rats. It stabilizes ErbB2 and promotes nuclear translocation of Gab1 and ERK.
Title: Heat Shock Protein 90 is Required for cAMP-Induced Differentiation in Rat Primary Schwann Cells.
Hsp90 is involved in the activation of the Raf/Mek/Erk pathway via stabilization of c-Raf in cardiomyocytes.
Title: Heat-shock protein 90 modulates cardiac ventricular hypertrophy via activation of MAPK pathway.
This study results showed that antipsychotics, particularly those recently synthesized, exerted similar GABAergic interneuron genesis effects on NG2(+) neuronal/glial progenitor cells in the adult rat brain by increasing cellular HSP90 production.
Title: Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Blocking the function of HSP90 with the HSP90 inhibitor geldanamycin or siRNA targeting HSP90 prevented the protection of HPC and the HPC-induced association of Cx43, indicating that mitochondrial HSP90 was important for mitochondrial translocation of Cx43 during HPC.
Title: Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.
Title: Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S4173 (e-PCR)
- UniSTS:43598

Hspca (e-PCR), detects polymorphism
- UniSTS:461999

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables CTP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables Rho GDP-dissociation inhibitor binding	IDA Inferred from Direct Assay more info	PubMed
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
enables TPR domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables UTP binding	IDA Inferred from Direct Assay more info	PubMed
enables dATP binding	IDA Inferred from Direct Assay more info	PubMed
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase regulator activity	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein carrier chaperone	NAS Non-traceable Author Statement more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables sulfonylurea receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone-mediated autophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in neurofibrillary tangle assembly	IEA Inferred from Electronic Annotation more info
involved_in neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein complex stability	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle contraction	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomerase holoenzyme complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic growth cone	ISO Inferred from Sequence Orthology more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in lysosomal membrane	NAS Non-traceable Author Statement more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed
located_in sperm plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock protein HSP 90-alpha

Names: HSP 86; heat shock 86 kDa; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1

NP_786937.1

EC 3.6.4.10

XP_063117854.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.