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    Sp9 Sp9 transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366078, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Sp9provided by RGD
    Official Full Name
    Sp9 transcription factorprovided by RGD
    Primary source
    RGD:1559457
    See related
    EnsemblRapid:ENSRNOG00000028187 AllianceGenome:RGD:1559457
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559457
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic limb morphogenesis and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 6.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sp9 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78554345..78556875)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58146826..58149357)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (59981959..59984489)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Obg-like ATPase 1 Neighboring gene transfer RNA valine (anticodon AAC) 24 Neighboring gene 60S ribosomal protein L27-like Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene secernin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Kawakami Y, et al. Development, 2004 Oct. PMID 15358670
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp9
    Names
    trans-acting transcription factor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191902.1 → NP_001178831.1  transcription factor Sp9

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZZ24
      Related
      ENSRNOP00000035929.3, ENSRNOT00000030460.6
      Conserved Domains (4) summary
      sd00017
      Location:337 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:392 → 414
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:378 → 401
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:19 → 333
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78554345..78556875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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