Raet1l retinoic acid early transcript 1L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Raet1lprovided by RGD
Official Full Name: retinoic acid early transcript 1Lprovided by RGD
Primary source: RGD:1308785
See related: EnsemblRapid:ENSRNOG00000023659 AllianceGenome:RGD:1308785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable natural killer cell lectin-like receptor binding activity. Involved in positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human RAET1E (retinoic acid early transcript 1E). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 1p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (3799823..3804799, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (1979433..1984410, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (114233896..114234243)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of retinoic acid early transcript 1 (a ligand for NKG2D receptor) makes certain tumor cells susceptible to killing in vitro by a subset of monocytes/macrophages positive for both CD4 and CD8 antigens.
Title: Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid early transcript 1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013063.2 → NP_001013081.2 retinoic acid early transcript 1L precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZTU3, Q6AYE9

Related

ENSRNOP00000082608.1, ENSRNOT00000104454.2

Conserved Domains (1) summary

cl08246
Location:33 → 206

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2