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    RT1-CE11 RT1 class I, locus CE11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 414791, updated on 9-Dec-2024

    Summary

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    Symbol
    RT1-CE11provided by RGD
    Full Name
    RT1 class I, locus CE11provided by RGD
    Primary source
    RGD:1359483
    See related
    AllianceGenome:RGD:1359483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RT1-CE10
    Summary
    Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RT1-CE11 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3355422..3385063, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3355393..3358520, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098828 Neighboring gene RT1 class I, locus CE12 Neighboring gene VPS52 subunit of GARP complex, pseudogene 6 Neighboring gene VPS52 subunit of GARP complex, pseudogene 5 Neighboring gene uncharacterized LOC120098832 Neighboring gene LOC224733l-8 pseudogene Neighboring gene Cdk2ap1-ps5 pseudogene Neighboring gene LOC224733l-7 pseudogene Neighboring gene RT1 class I, locus CE10 Neighboring gene RT1 class I, locus CE9, pseudogene 1 Neighboring gene RT1 class I, locus CE5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats. Dai KZ, et al. J Immunol, 2018 Apr 15. PMID 29531166, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RT1 class I, locus CE11
    Names
    H-2 class I histocompatibility antigen, alpha chain-like
    RT1 class I, CE10
    RT1 class I, CE11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008834.2 → NP_001008834.1  RT1 class I, locus CE11 precursor

      See identical proteins and their annotated locations for NP_001008834.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      Q6MG33
      Conserved Domains (3) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:340 → 366
      MHC_I_C; MHC_I C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3355422..3385063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279413.1 → XP_063135483.1  RT1 class I, locus CE11 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K1E1

    2. XM_063279410.1 → XP_063135480.1  RT1 class I, locus CE11 isoform X2

    3. XM_063279411.1 → XP_063135481.1  RT1 class I, locus CE11 isoform X3

    4. XM_063279409.1 → XP_063135479.1  RT1 class I, locus CE11 isoform X1

    5. XM_063279415.1 → XP_063135485.1  RT1 class I, locus CE11 isoform X7

      UniProtKB/TrEMBL
      A0A2P1NRY1

    6. XM_063279412.1 → XP_063135482.1  RT1 class I, locus CE11 isoform X4

    7. XM_063279416.1 → XP_063135486.1  RT1 class I, locus CE11 isoform X8

      UniProtKB/TrEMBL
      A0A2P1NRX9

    8. XM_063279414.1 → XP_063135484.1  RT1 class I, locus CE11 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K1E1

    RNA

    1. XR_010060749.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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