Tgs1 trimethylguanosine synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgs1provided by RGD
Official Full Name: trimethylguanosine synthase 1provided by RGD
Primary source: RGD:1309953
See related: EnsemblRapid:ENSRNOG00000008156 AllianceGenome:RGD:1309953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ncoa6ip
Summary: Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 72.8), Spleen (RPKM 57.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (21322492..21356017)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (16524864..16558399)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (16413356..16446881)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIMT Controls Insulin Synthesis and Secretion through PDX1.
Title: PIMT Controls Insulin Synthesis and Secretion through PDX1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138074 (e-PCR)
- UniSTS:220161

AU028229 (e-PCR)
- UniSTS:112530

D10Chm27 (e-PCR)
- UniSTS:518088

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA cap trimethylguanosine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap trimethylguanosine synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine cap hypermethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine cap hypermethylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trimethylguanosine synthase

Names: PIMT; PIPMT; PRIP-interacting protein with methyltransferase motif; cap-specific guanine-N(2) methyltransferase; nuclear receptor coactivator 6 interacting protein; trimethylguanosine synthase homolog

NP_001101374.1

EC 2.1.1.-

XP_038965688.1

EC 2.1.1.-

XP_063143595.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107904.1 → NP_001101374.1 trimethylguanosine synthase

See identical proteins and their annotated locations for NP_001101374.1

Status: PROVISIONAL

Source sequence(s)

CH473984

UniProtKB/Swiss-Prot

P85107

UniProtKB/TrEMBL

A6JFK6

Related

ENSRNOP00000010783.5, ENSRNOT00000010783.7

Conserved Domains (1) summary

pfam09445
Location:685 → 837

Methyltransf_15; RNA cap guanine-N2 methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

21322492..21356017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109760.2 → XP_038965688.1 trimethylguanosine synthase isoform X1

Conserved Domains (2) summary

NF033845
Location:273 → 436

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

cl17173
Location:684 → 836

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063287525.1 → XP_063143595.1 trimethylguanosine synthase isoform X2