Acsm4 acyl-CoA synthetase medium-chain family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsm4provided by RGD
Official Full Name: acyl-CoA synthetase medium-chain family member 4provided by RGD
Primary source: RGD:727928
See related: EnsemblRapid:ENSRNOG00000014726 AllianceGenome:RGD:727928
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Omacs
Summary: Enables decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Involved in acyl-CoA metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ACSM4 (acyl-CoA synthetase medium chain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 4.5), Thymus (RPKM 3.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183485259..183509712)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (174053931..174078345)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189432604..189458799)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that olfactory medium-chain acyl-CoA synthetase (O-MACS) may play an important role in processing odorants in a zone-specific manner, or in zonal patterning of the olfactory epithelium during development.
Title: O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat362 (e-PCR), detects polymorphism
- UniSTS:227154

RH144159 (e-PCR)
- UniSTS:233405

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables decanoate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty-acyl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables odorant binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A synthetase ACSM4, mitochondrial

Names: O-MACS; olfactory specific medium-chain acyl CoA synthetase

NP_859046.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181695.2 → NP_859046.1 acyl-coenzyme A synthetase ACSM4, mitochondrial precursor

See identical proteins and their annotated locations for NP_859046.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q7TN78

UniProtKB/TrEMBL

A6I8M5

Related

ENSRNOP00000031354.3, ENSRNOT00000034610.6

Conserved Domains (1) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)