U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mc2r melanocortin 2 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282839, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mc2rprovided by RGD
    Official Full Name
    melanocortin 2 receptorprovided by RGD
    Primary source
    RGD:628649
    See related
    EnsemblRapid:ENSRNOG00000072071 AllianceGenome:RGD:628649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in placenta development. Predicted to be active in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 393.7) and Muscle (RPKM 25.0) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mc2r in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (64279878..64291775, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (62001980..62015567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (64166959..64178729, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene melanocortin 5 receptor Neighboring gene uncharacterized LOC102548061 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors. Cai G, et al. Sci Rep, 2016 Feb 12. PMID 26868281, Free PMC Article
    2. Metallothionein and zinc metabolism in endotoxin shock rats. Abe S, et al. Experientia Suppl, 1987. PMID 2822467
    3. Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in rat sympathetic ganglia and up-regulated by stress. Nankova BB, et al. Neurosci Lett, 2003 Jul 3. PMID 12812827
    4. Immunohistochemical localization of the ACTH (MC-2) receptor in the rat placenta and adrenal gland. Izumi S, et al. Arch Histol Cytol, 2004 Dec. PMID 15781985
    5. Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway. Tang X, et al. J Cell Biochem, 2018 Nov. PMID 29943847

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data demonstrated that the abnormal proliferation of vascular smooth muscle cells induced by conditions of high cyclic strain is in part attributed to ACTH and its receptor MC2R.
      Title: Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway.
    2. Data suggest that increases in adrenal blood flow induced by Ang II (angiotensin II)/Agtr2 signaling are mediated by release of nitric oxide and EETs (epoxyeicosatrienoic acids); increases in adrenal blood flow with ACTH (adrenocorticotropic hormone)/Mc2r receptor signaling are mediated by EETs only. (Agtr2 = angiotensin II receptor; Mc2r = ACTH receptor)
      Title: Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo.
    3. Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.
      Title: Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors.
    4. The results showed that the haplotype TCCT in MC2R promoter significantly led to increased MC2R expression and strong responses to adrenocorticotropin hormone.
      Title: ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH.
    5. Upregulation of adrenal MC2 and AT(2) receptors seems to be involved in the stimulated facilitation of adrenal corticosterone release for effectuating the stimulated stress responses.
      Title: Stress sensitivity is increased in transgenic rats with low brain angiotensinogen.
    6. CRF is released in the locus coerulus during swim stress to activate this system and initiate cellular trafficking of the receptor that determines subsequent sensitivity of locus coerulus neurons to CRF.
      Title: Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corticotropin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in placenta development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adrenocorticotropic hormone receptor
    Names
    melanocortin 2 receptor (adrenocorticotropic hormone)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100491.1 → NP_001093961.1  adrenocorticotropic hormone receptor

      See identical proteins and their annotated locations for NP_001093961.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Related
      ENSRNOP00000103356.1, ENSRNOT00000135912.1
      Conserved Domains (1) summary
      cd15350
      Location:25 → 287
      7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      64279878..64291775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277136.1 → XP_063133206.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    2. XM_063277135.1 → XP_063133205.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Related
      ENSRNOP00000102791.1, ENSRNOT00000126493.1

    3. XM_063277140.1 → XP_063133210.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    4. XM_063277137.1 → XP_063133207.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Related
      ENSRNOP00000111537.1, ENSRNOT00000164299.1

    5. XM_063277138.1 → XP_063133208.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Related
      ENSRNOP00000103024.1, ENSRNOT00000134916.1

    6. XM_063277139.1 → XP_063133209.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    7. XM_008772094.4 → XP_008770316.1  adrenocorticotropic hormone receptor isoform X1

      See identical proteins and their annotated locations for XP_008770316.1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Conserved Domains (1) summary
      cd15350
      Location:25 → 287
      7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    8. XM_008772095.4 → XP_008770317.1  adrenocorticotropic hormone receptor isoform X1

      See identical proteins and their annotated locations for XP_008770317.1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
      Related
      ENSRNOP00000110155.1, ENSRNOT00000148665.1
      Conserved Domains (1) summary
      cd15350
      Location:25 → 287
      7tmA_MC2R_ACTH_R; melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. XM_063277141.1 → XP_063133211.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    10. XM_063277144.1 → XP_063133214.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    11. XM_063277143.1 → XP_063133213.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    12. XM_063277142.1 → XP_063133212.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6

    13. XM_063277145.1 → XP_063133215.1  adrenocorticotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A6IXY0, G3V848, Q8CIX6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous