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    Abcf2 ATP binding cassette subfamily F member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcf2provided by RGD
    Official Full Name
    ATP binding cassette subfamily F member 2provided by RGD
    Primary source
    RGD:1304942
    See related
    EnsemblRapid:ENSRNOG00000010609 AllianceGenome:RGD:1304942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity. Orthologous to several human genes including ABCF2 (ATP binding cassette subfamily F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 330.4), Muscle (RPKM 293.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abcf2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11485865..11500067)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10594802..10607620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7122850..7135607)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D3 Neighboring gene chondroitin polymerizing factor 2 Neighboring gene microRNA 671 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene ankyrin repeat and SOCS box-containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family F member 2
    Names
    ATP-binding cassette, sub-family F (GCN20), member 2
    ATP-binding cassette, subfamily F (GCN20), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398837.1 → NP_001385766.1  ATP-binding cassette sub-family F member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A096MIV5
      Conserved Domains (1) summary
      COG0488
      Location:87 → 607
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    2. NM_001398838.1 → NP_001385767.1  ATP-binding cassette sub-family F member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A096MIV5
      Conserved Domains (1) summary
      COG0488
      Location:86 → 606
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    3. NM_001398839.1 → NP_001385768.1  ATP-binding cassette sub-family F member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K762, A2VD14
      Conserved Domains (1) summary
      COG0488
      Location:84 → 604
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    RNA

    1. NR_174136.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    2. NR_174137.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11485865..11500067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235934.5 → XP_006235996.1  ATP-binding cassette sub-family F member 2 isoform X4

      UniProtKB/TrEMBL
      A0A096MIV5
      Conserved Domains (3) summary
      cd03221
      Location:90 → 306
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      COG0488
      Location:87 → 577
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      pfam12848
      Location:300 → 386
      ABC_tran_Xtn; ABC transporter

    2. XM_063285944.1 → XP_063142014.1  ATP-binding cassette sub-family F member 2 isoform X5

      UniProtKB/TrEMBL
      A0A096MIV5

    3. XM_063285945.1 → XP_063142015.1  ATP-binding cassette sub-family F member 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K762

    4. XM_039107496.2 → XP_038963424.1  ATP-binding cassette sub-family F member 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K762
      Conserved Domains (1) summary
      COG0488
      Location:83 → 603
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    5. XM_063285946.1 → XP_063142016.1  ATP-binding cassette sub-family F member 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K762

    6. XM_006235930.5 → XP_006235992.1  ATP-binding cassette sub-family F member 2 isoform X1

      See identical proteins and their annotated locations for XP_006235992.1

      UniProtKB/TrEMBL
      A0A096MIV5
      Related
      ENSRNOP00000067893.3, ENSRNOT00000076418.4
      Conserved Domains (1) summary
      COG0488
      Location:87 → 607
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    7. XM_063285942.1 → XP_063142012.1  ATP-binding cassette sub-family F member 2 isoform X4

      UniProtKB/TrEMBL
      A0A096MIV5
      Related
      ENSRNOP00000074076.3, ENSRNOT00000088399.3

    8. XM_039107495.2 → XP_038963423.1  ATP-binding cassette sub-family F member 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K762, A2VD14
      Conserved Domains (1) summary
      COG0488
      Location:84 → 604
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109666.1: Suppressed sequence

      Description
      NM_001109666.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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