Itln1 intelectin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itln1provided by RGD
Official Full Name: intelectin 1provided by RGD
Primary source: RGD:1561048
See related: EnsemblRapid:ENSRNOG00000004678 AllianceGenome:RGD:1561048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Predicted to be involved in several processes, including positive regulation of D-glucose import; protein homotrimerization; and response to nematode. Predicted to be located in brush border membrane and membrane raft. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Orthologous to several human genes including ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 9.0), Liver (RPKM 1.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86464641..86490655)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83932234..83958243)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89919570..89929774)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Innovative insights: ITLN1 modulates renal injury in response to radiation.
Title: Innovative insights: ITLN1 modulates renal injury in response to radiation.
Omentin-1 attenuates glucocorticoid-induced cardiac injury by phosphorylating GSK3beta.
Title: Omentin-1 attenuates glucocorticoid-induced cardiac injury by phosphorylating GSK3β.
These data suggest that omentin treatment may contribute to decrease susceptibility to docetaxel-induced cardiotoxicity.
Title: Omentin protects H9c2 cells against docetaxel cardiotoxicity.
Data suggest that the successful delivery of LV-intelectin-1 ameliorated ischemic brain injury. It promoted endothelial cell function and revasc ularization, and inhibited apoptosis in response to ischemia by stimulating the Akt-eNOS signaling pathway.
Title: Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia.
analysis of expression of maternal omentin-1 in humans and in the rat animal model
Title: Maternal serum omentin-1 profile is similar in humans and in the rat animal model.
Omentin levels may be a biochemical indicator to detect acute mesenteric ischemia.
Title: Serum omentin levels predicts mesenteric ischemia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in response to nematode	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: intelectin-1

Names: intelectin 1 (galactofuranose binding); intelectin 1 (galactofuranose binding)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034946.1 → NP_001030118.1 intelectin-1 precursor

See identical proteins and their annotated locations for NP_001030118.1

Status: PROVISIONAL

Source sequence(s)

BC099766

UniProtKB/TrEMBL

E9PT30, Q499T8

Related

ENSRNOP00000006196.4, ENSRNOT00000006196.6

Conserved Domains (1) summary

cl00085
Location:37 → 82

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...