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    Trpc3 transient receptor potential cation channel, subfamily C, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60395, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trpc3provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 3provided by RGD
    Primary source
    RGD:61973
    See related
    EnsemblRapid:ENSRNOG00000016070 AllianceGenome:RGD:61973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trrp3; TrpC3c
    Summary
    Enables calcium-activated cation channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 97.8), Brain (RPKM 72.2) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trpc3 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121409436..121487095, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119481313..119619333, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123329954..123467574, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene ribosomal protein L7, pseudogene 22 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene THUMP domain containing 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity  
    enables calcium channel activity  
    enables calcium-activated cation channel activity PubMed 
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables metal ion binding  
    enables store-operated calcium channel activity  
    enables store-operated calcium channel activity  
    enables store-operated calcium channel activity  
    Component Evidence Code Pubs
    part_of cation channel complex  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    short transient receptor potential channel 3
    Names
    ion channel protein
    trp-related protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415005.1NP_001401934.1  short transient receptor potential channel 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      F1LNQ7, Q9JMI9
      UniProtKB/TrEMBL
      A0A0G2KAL8
      Related
      ENSRNOP00000046270.5, ENSRNOT00000046700.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      121409436..121487095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103015.2XP_038958943.1  short transient receptor potential channel 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAL8
      Related
      ENSRNOP00000100915.1, ENSRNOT00000080207.4
      Conserved Domains (2) summary
      TIGR00870
      Location:39833
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:89120
      ANK; ANK repeat [structural motif]
    2. XM_008760941.4XP_008759163.1  short transient receptor potential channel 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAL8
      Related
      ENSRNOP00000095733.2, ENSRNOT00000109104.3
      Conserved Domains (2) summary
      TIGR00870
      Location:84850
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:134165
      ANK; ANK repeat [structural motif]
    3. XM_039103014.2XP_038958942.1  short transient receptor potential channel 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAL8
      Conserved Domains (2) summary
      TIGR00870
      Location:84877
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:134165
      ANK; ANK repeat [structural motif]
    4. XM_063282439.1XP_063138509.1  short transient receptor potential channel 3 isoform X4

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