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    Rad54b RAD54 homolog B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad54bprovided by RGD
    Official Full Name
    RAD54 homolog Bprovided by RGD
    Primary source
    RGD:1306507
    See related
    EnsemblRapid:ENSRNOG00000039949 AllianceGenome:RGD:1306507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fsbp; RGD1306507
    Summary
    Predicted to enable DNA translocase activity and identical protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including DNA damage response; determination of adult lifespan; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 16.2), Spleen (RPKM 9.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad54b in Genome Data Viewer
    Location:
    5q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (29829465..29901967)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25032112..25104630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25140531..25214469)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene chromatin target of PRMT1 protein-like Neighboring gene vir like m6A methyltransferase associated Neighboring gene U6atac minor spliceosomal RNA Neighboring gene fibrinogen silencer binding protein Neighboring gene uncharacterized LOC102552309 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. Lau KF, et al. Neuroreport, 2010 Aug 4. PMID 20531236, Free PMC Article
    2. Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. Kirshner M, et al. DNA Repair (Amst), 2009 Feb 1. PMID 19061978
    3. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Wesoly J, et al. Mol Cell Biol, 2006 Feb. PMID 16428451, Free PMC Article
    4. Regulation of homologous recombination in eukaryotes. Heyer WD, et al. Annu Rev Genet, 2010. PMID 20690856, Free PMC Article
    5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fibrinogen silencer-binding protein; DNA repair and recombination protein RAD54B
    Names
    RAD54, S. cerevisiae, homolog of, B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191755.4 → NP_001178684.2  fibrinogen silencer-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6II66, F1LYB7
      Related
      ENSRNOP00000058084.4, ENSRNOT00000061370.6
      Conserved Domains (2) summary
      COG0553
      Location:276 → 795
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:276 → 510
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      29829465..29901967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109806.2 → XP_038965734.1  DNA repair and recombination protein RAD54B isoform X2

      Conserved Domains (1) summary
      cl28899
      Location:299 → 463
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_039109802.2 → XP_038965730.1  DNA repair and recombination protein RAD54B isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM82, A6II66
      Conserved Domains (2) summary
      COG0553
      Location:299 → 818
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:299 → 533
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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