Srgn serglycin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srgnprovided by RGD
Official Full Name: serglycinprovided by RGD
Primary source: RGD:619969
See related: EnsemblRapid:ENSRNOG00000000394 AllianceGenome:RGD:619969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pgsg
Summary: Enables collagen binding activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; negative regulation of bone mineralization; and protein localization to secretory granule. Located in Golgi membrane and zymogen granule. Orthologous to human SRGN (serglycin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 374.8), Lung (RPKM 299.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30985508..31022296, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30442810..30479549, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32120317..32158071, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127524 (e-PCR)
- UniSTS:210834

RH140911 (e-PCR)
- UniSTS:222926

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in T cell secretory granule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of granzyme B location in T cell secretory granule	ISO Inferred from Sequence Orthology more info
involved_in maintenance of granzyme B location in T cell secretory granule	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protease location in mast cell secretory granule	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protease location in mast cell secretory granule	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in mast cell secretory granule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in secretory granule organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in mast cell granule	ISO Inferred from Sequence Orthology more info
located_in mast cell granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serglycin

Names: PG19 core protein; chondroitin sulfate proteoglycan core protein; cytolytic granule proteoglycan core protein; proteoglycan 10K core protein; proteoglycan peptide core protein; secretory granule proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.